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Comparative effects of bisoprolol and verapamil on central and peripheral BP in patients with arterial hypertension

Orlova Ia. A.1, Mikhaylov G. V.2, Vitsenya M. V.2
1 – Federal State Budgetary Educational Institution of Higher Education, "M.V. Lomonosov Moscow State University", Leninskie Gory 1, GSP-1, Moscow 119991
2 – Federal State Budgetary Institution, "Russian Cardiology Science and Production Center" of the Ministry of Health of the Russian Federation, 3rd Cherepkovskaya 15a, Moscow 121552

Keywords: central pressure, vascular stiffness, augmentation index, pulse wave velocity, verapamil, bisoprolol

DOI: 10.18087/rhj.2017.1.2277

Background. Emergence of noninvasive methods for measuring central blood pressure along with reports of its essential effect on LV hypertrophy, coronary and kidney perfusion and, therefore, more strict relationship with development of cardiovascular complications allots new tasks of evaluating the efficacy of drug therapy for AH. Aim. To compare effects of bisoprolol and verapamil on peripheral and central blood pressure in patients with AH. Materials and methods. 60 patients (mean age, 55±12; 29 men and 31 women) with grade 1–2 AH and heart rate (HR) higher than 75 bpm were included. Central systolic BP (cSBP), central pulse BP (cPBP), peripheral systolic (SBP) and peripheral pulse BP (PBP), augmentation index (AI%), HR , brachial-ankle pulse wave velocity (baPWV), and carotid-femoral pulse wave velocity (cf PWV) were measured. The measurements were performed at enrollment and after 3 months of bisoprolol or verapamil treatment. Results. Both therapies resulted in decreased SBP, PBP and HR. The bisoprolol treatment decreased cSBP (from 142.7 to 136.6 mm Hg) and cPBP (from 49.7 to 43.3 mm Hg) and increased AI% (from 31.5 to 35.2). The verapamil treatment reduced cSBP (from 135.4 to 126.9 mm Hg) whereas AI% and cPBP remained unchanged. Both drugs reduced stiffness but the effect of bisoprolol was more pronounced.
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Orlova Ia.A., Mikhaylov G.V., Vitsenya M.V. Comparative effects of bisoprolol and verapamil on central and peripheral BP in patients with arterial hypertension. Russian Heart Journal. 2017;16 (1):59–65.

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