2016


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2016/№5

Arterial stiffness in patients at high cardiovascular risk with disturbed bone mineral metabolism

Aslanyan N. S., Blankova Z. N., Vitsenya M. V., Smirnova M. D., Mikhaylov G. V., Ageev F. T.
Federal State Budgetary Institution, "Russian Cardiology Science and Production Center" of the RF Ministry of Health Care, 3rd Cherepkovskaya 15a, Moscow 121552

Keywords: arterial stiffness, high cardiovascular risk, osteoporosis, disturbed bone mineral density

DOI: 10.18087/rhj.2016.5.2270

Background.Increased arterial stiffness is considered a factor enhancing the risk of cardiovascular complications (CVC) in patients with osteoporosis. Aim. To study possible interrelations between arterial stiffness and parameters of disturbed bone mineral metabolism in patients at high cardiovascular risk. Materials and methods. Carotid-femoral pulse wave velocity (PWVcf, applanation tonometry) and brachial-ankle pulse wave velocity (PWVba), three-dimensional sphygmography), augmentation index (AI), and thoracic (BMDt) and femoral neck (BMDfn) bone mineral density (DEXA) were measured in 137 patients with high CVC risk according to the SCORE scale and without ischemic heart disease. Based on severity of BMD disorders the patients were divided into three groups, with normal BMD (n=29), osteoporosis (n=45), and osteopenia (n=63). Results. Patients of the osteoporosis and osteopenia groups had statistically significantly higher values of PWVba [14.1 (12.8, 16.4) m / s and 13.5 (12.5, 15.7) m / s, respectively] than patients without BMD disorders [12.9 (11.8, 13.9) m / s. PWV values depended on age, BP, AI, glomerular filtration rate, and alkaline phosphatase (AP) levels (p<0.05 for all). AF and BMDt were inversely correlated (p<0,05). Conclusion. Patients with high cardiovascular risk and disturbed BMD had higher values of arterial stiffness compared to patients with normal BMD. The observed correlations between parameters of arterial stiffness and bone mineral metabolism may evidence the presence of pathogenetic links between damages of arterial wall and bone tissue in these patients.
  1. Kado DM, Browner WS, Blackwell T, Gore R, Cummings SR. Rate of bone loss is associated with mortality in older women: a prospective study. J Bone Miner Res. 2000 Oct;15 (10):1974–80.
  2. Browner WS, Seeley DG, Vogt TM, Cummings SR. Non-trauma mortality in elderly women with low bone mineral density. Study of Osteoporotic Fractures Research Group. Lancet. 1991 Aug 10;338 (8763):355–8.
  3. Jørgensen L, Engstad T, Jacobsen BK. Bone mineral density in acute stroke patients: low bone mineral density may predict first stroke in women. Stroke. 2001 Jan;32 (1):47–51.
  4. Mussolino ME, Gillum RF, Madans JH. Bone mineral density and stroke risk. Stroke. 2001 Dec 1;32 (12):2956–7.
  5. Trivedi DP, Khaw KT. Bone mineral density at the hip predicts mortality in elderly men. Osteoporos Int. 2001;12 (4):259–65.
  6. Qu X, Huang X, Jin F, Wang H, Hao Y, Tang T, Dai K. Bone mineral density and all-cause, cardiovascular and stroke mortality: a meta-analysis of prospective cohort studies. Int J Cardiol. 2013 Jun 20;166 (2):385–93.
  7. Safar ME, O’Rourke MF. 1st Edition Handbook of Hypertension Series. Arterial stiffness in hypertension. Volume 23. – Elsevier, 2006. – P379–397.
  8. Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Bohm M et al. 2013 ESH / ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2013 Jul;31 (7):1281–357.
  9. Агеев Ф. Т., Баринова И. В., Середенина Е. М., Орлова Я. А., Кузьмина А. Е., Масенко В. П., Кочетова А. Г. Остеопороз и жесткость артерий: исследование 103 женщин с умеренным и низким риском развития сердечно-сосудистых заболеваний. Кардиология. 2013;53 (6):51–8 [Ageev F. T., Barinova I. V., Seredenina E. M., Orlova Ya. A., Kuz`mina A. E., Masenko V. P., Kochetova A. G. Osteoporoz i zhestkost` arterij: issledovanie 103 zhenshhin s umerenny`m i nizkim riskom razvitiya serdechnososudisty` x zabolevanij. Kardiologiya. 2013;53 (6):51–8].
  10. Sumino H, Ichikawa S, Kasama S, Takahashi T, Kumakura H, Takayama Y et al. Elevated arterial stiffness in postmenopausal women with osteoporosis. Maturitas. 2006 Oct 20;55 (3):212–8.
  11. Frost ML, Grella R, Millasseau SC, Jiang BY, Hampson G, Fogelman I, Chowienczyk PJ. Relationship of calcification of atherosclerotic plaque and arterial stiffness to bone mineral density and osteoprotegerin in postmenopausal women referred for osteoporosis screening. Calcif Tissue Int. 2008 Aug;83 (2):112–20.
  12. Mikumo M, Okano H, Yoshikata R, Ishitani K, Ohta H. Association between lumbar bone miner-al density and vascular stiffness as assessed by pulse wave velocity in postmenopausal women. J Bone Miner Metab. 2009;27 (1):89–94.
  13. Царенок С. Ю., Горбунов В. В., Панина Е. С., Аксенова Т. А., Терешков М. П., Верхотурова С. В., Гагаркина Л. С. Артериальная ригидность и плотность костной ткани у женщин с ишемической болезнью сердца в сочетании с тяжелым остеопорозом. Клиническая медицина. 2015;93 (3):63–8 [Czarenok S. Yu., Gorbunov V. V., Panina E. S., Aksenova T. A., Tereshkov M. P., Verxoturova S. V., Gagarkina L. S. Arterial`naya rigidnost` i plotnost` kostnoj tkani u zhenshhin s ishemicheskoj bolezn`yu serdcza v sochetanii s tyazhely`m osteoporozom. Klinicheskaya mediczina. 2015;93 (3):63–8].
  14. Tanaka H, Munakata M, Kawano Y, Ohishi M, Shoji T, Sugawara J et al. Comparison between carotid-femoral and brachial-ankle pulse wave velocity as measures of arterial stiffness. J Hypertens. 2009 Oct;27 (10):2022–7.
  15. London GM, Blacher J, Pannier B, Guérin AP, Marchais SJ, Safar ME. Arterial wave reflections and survival in end-stage renal failure. Hypertension. 2001 Sep;38 (3):434–8.
  16. Ross PD, Kress BC, Parson RE, Wasnich RD, Armour KA, Mizrahi IA. Serum bone alkaline phosphatase and calcaneus bone density predict fractures: a prospective study. Osteoporos Int. 2000;11 (1):76–82.
  17. Matsushita K, van der Velde M, Astor BC, Woodward M, Levey AS, de Jong PE et al. Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis. Lancet. 2010 Jun 12;375 (9731):2073–81.
  18. Dooley AC, Weiss NS, Kestenbaum B. Increased Risk of hip fracture among men with CKD. Am J Kidney Dis. 2008 Jan;51 (l): 38–44.
  19. Ермоленко В. М., Волгина Г. В., Добронравова В. А., Рожинская Л. Я., Смирнов А. В., Томилина Н. А. и др. Национальные рекомендации по минеральным и костным нарушениям при хронической болезни почек. Российское диализное общество (май 2010 г.). Нефрология и диализ. 2011;13 (1):33–51 [Ermolenko V. M., Volgina G. V., Dobronravova V. A., Rozhinskaya L. Ya., Smirnov A. V., Tomilina N. A. i dr. Naczional`ny`e rekomendaczii po mineral`ny`m i kostny`m narusheniyam pri xronicheskoj bolezni pochek. Rossijskoe dializnoe obshhestvo (maj 2010 g.). Nefrologiya i dializ. 2011;13 (1):33–51].
  20. Georgianos PI, Sarafidis PA, Liakopoulos V. Arterial Stiffness: a novel risk factor for kidney injury progression? Am J Hypertens. 2015 Aug;28 (8):958–65.
  21. London GM. Soft bone – hard arteries: a link? Kidney Blood Press Res. 2011;34 (4):203–8.
  22. Rubin MR, Silverberg SJ. Vascular calcification and osteoporosisthe nature of the nexus. J Clin Endocrinol Metab. 2004 Sep;89 (9):4243–5.
  23. Shimizu H, Nakagami H, Osako MK, Hanayama R, Kunugiza Y, Kizawa T et al. Angiotensin II accelerates osteoporosis by activating osteoclasts. FASEB J. 2008 Jul;22 (7):2465–75.
Aslanyan N. S., Blankova Z. N., Vitsenya M. V., Smirnova M. D., Mikhaylov G. V., Ageev F. T. Arterial stiffness in patients at high cardiovascular risk with disturbed bone mineral metabolism. Russian Heart Journal. 2016;15 (5):363–368

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