2016


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2016/№2

Selection of antihypertensive therapy for elderly patients

Drozdova L. Yu., Egorov V. A.
Federal State Budgetary Institution, “National Research Center for Preventive Medicine”
of the RF Ministry of Health Care, Petroverigsky Per. 10, Bldg. 3, Moscow 101990

Keywords: hyperpiesis, elderly age, antihypertensive therapy, stroke, cognitive abnormality

DOI: 10.18087 / rhj.2016.2.2175

This article presents results of studies focusing on efficacy and safety of antihypertensive therapy in elderly patients. Analyzed studies included primarily patients with isolated systolic AH (ISAH). According to reports of SYST-EUR and SYST-CHINA studies, treatment of elderly patients with antihypertensive drugs based on a combination of Ca2+ antagonists (CA) and ACE inhibitors (ACEI) statistically significantly reduced incidence of stroke and cardiovascular events as well as cardiovascular and all-cause mortality. Additional analysis of the continuation, open-label phase of the SYST-EUR study, which compared nitrendipine monotherapy with a nitrendipine and enalapril combination treatment showed a significant decrease in systolic BP and an additional reduction in the risk of stroke and cardiovascular complications in the combination treatment group. Notably, the treatment including the CA nitrendipine reduced incidence of cognitive disorders, which is important in selecting therapy for elderly patients with AH.
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Drozdova L. Yu., Egorov V. A. Selection of antihypertensive therapy for elderly patients. Russian Heart Journal. 2016;15 (2):123–126

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