2016


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2016/№2

Gender-specific features of interrelation between vascular stiffness and left ventricular diastolic function in patients with essential hypertension

Polupanov A. G.1, Mamasaidov Zh. A.2, Alimbekova D. B.1, Geleskhanova Yu. N.1, Cheskidobva N. B.1, Romanova G. A.1, Dzhumagulova A. S.1
1 – Academician Mirsaid Mirrakhimov National Center of Cardiology and Therapy at the Ministry of Health Care of the Kyrgyz Republic, Togolok Moldo 3, Bishkek, Kyrgyz Republic
2 – State Educational Institution of Higher Profession Education, “B. N. Eltsyn Kyrgyz-Russian Slavic University” Kievskaya 44, Bishkek, the Kyrgys Republic

Keywords: essential hypertension, diastolic function, vascular stiffness, augmentation index

DOI: 10.18087/rhj.2016.2.2125

Background. Several studies have reported higher incidence of diastolic disorders and CHF with preserved EF in women. Aim. To study gender-specific features of the interrelation between arterial stiffness and left ventricular diastolic dysfunction (DD) in patients with essential hypertension (EH). Materials and methods. 155 patients with EH aged 30–70 were evaluated. General clinical examination was performed; glucose, creatinine and lipid spectrum (LDL, HDL, TG) were measured; carotid duplex scanning was performed; and arterial stiffness was measured by pulse wave contour analysis. Results. Females had more pronounced disorders of vascular stiffness evident as higher values of augmentation index. Arterial stiffness was associated with impaired LV diastolic function in patients of either sex. Furthermore, in women, LV DD was associated only with the stiffness index while in men, it was associated with both the stiffness index and increased amplitude of the reflected wave, the augmentation index.
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Polupanov A. G., Mamasaidov Zh. A., Alimbekova D. B., Geleskhanova Yu. N., Cheskidobva N. B., Romanova G. A., Dzhumagulova A. S. Gender-specific features of interrelation between vascular stiffness and left ventricular diastolic function in patients with essential hypertension. Russian Heart Journal. 2016;15 (2):117–122

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