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New oral anticoagulants in cardiologic practice: The issue of switching drugs and strategies for its solution

Malinova L. I.1, Podbolotov R. A.1, Denisova T. P.2
1 – Federal State Budgetary Institution, “Saratov Research Institute of Cardiology” at the RF Ministry of Health Care, Chernyshevskogo 141, Saratov 410028
2 – State Budgetary Educational Institution of Higher Professional Education, “V. I. Razumovsky Saratov State Medical University” of the RF Ministry of Health Care, Bolshaya Kazachjya 112, Saratov 410012

Keywords: anticoagulants, treatment, cardiovascular diseases

DOI: 10.18087/rhj.2015.6.2120

Background. Long-term anticoagulant support, which has become possible only after launching of oral anticoagulants (AC), is needed for prevention of thrombotic and thromboembolic complications of cardiovascular diseases (CVD). Aim. To evaluate state-of-the-art in switching from indirect oral AC (IDAC) to new oral AC (dabigatran etexilate, rivaroxaban, apixaban, edoxaban). Materials and methods. We have analyzed information from 425 sources indexed in bibliographic open-access databases using a modified PRISMA algorithm. Results. 36 publications issued between 2011 and 2015 were selected. Mean impact factor of journals where these reports were published was 4.637. Seven sources were indexes in eLibrary and 29 – in PubMed. Most of the publications were original studies (13) and reviews (13), none of which was systematic. Three reports focused on results of clinical studies; 3 reports used data of a registry, and one report described a clinical case. Conclusion. The performed analysis revealed a considerable shortage of evidence basis for switching from IDAC to new AC.
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Malinova L. I., Podbolotov R . A., Denisova T. P. New oral anticoagulants in cardiologic practice: The issue of switching drugs and strategies for its solution. Russian Heart Journal. 2015;14 (6):362–368

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