Practical aspects of using new oral anticoagulants in patients with atrial fibrillation
Averkova A. O.
Federal State Budgetary Institution, "Central Clinical Hospital with Outpatient Clinic" at the Department of Presidential Affairs, Marshala Timoshenko 15, Moscow 121359
Federal State Budgetary Institution, "Central Clinical Hospital with Outpatient Clinic" at the Department of Presidential Affairs, Marshala Timoshenko 15, Moscow 121359
Keywords: anticoagulants, CAD, treatment, atrial fibrillation
Atrial fibrillation (AF) is one of important causes for ischemic stroke. In recent years, treatment with new anticoagulants (NAC) instead of warfarin and its analogues has been recommended for virtually all AP patients with a considerable risk of embolic events. The NACs available for prevention of stroke in patients with AF include dabigatran, rivaroxaban, and apixaban. Five large Phase III clinical studies using dabigatran, rivaroxaban, apixaban and edoxaban in patients with nonvalvular AF were completed in 2015. On the whole, the studies showed similar efficacy and safety of each NAC as compared with warfarin. Clear understanding differences between NACs and vitamin K antagonists (VKA) as well as responsible use of any anticoagulant in routine practice are important to obtain maximum benefit of using these drugs. Clinical experience of using NACs outside studies is still rather limited. Further studies of correct NAC treatment will undoubtedly become important with expanding application of NAC therapies.
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Averkova A. O. Practical aspects of using new oral anticoagulants in patients with atrial fibrillation. Russian Heart Journal. 2015;14 (5):316–330