2015


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2015/№4

Comparative evaluation of compliance with therapy with fixed and non-fixed combinations of drugs for arterial hypertension

Grigorjeva N. Yu., Kuznetsov A. N., Koroleva M. E.
State Budgetary Educational Institution of Higher Professional Education, “Nizhny Novgorod State Medical Academy” of the RF Ministry of Healthcare, Minin and Pozharsky Square 10/1, Nizhny Novgorod 603005

Keywords: hyperpiesis, treatment compliance, bisoprolol, amlodipine, fixed combinations

DOI: 10.18087/rhj.2015.4.2111

Background. Most patients require two antihypertensive medicines to achieve their BP goal. One of rational combinations of antihypertensive drugs is a combination of β-blocker and dihydropyridine Ca2+ antagonist. Aim. To compare efficacies of and patient compliance with the AH treatment with fixed-dose and free combinations of bisoprolol and amlodipine. Materials and methods. 64 patients with stage 2 essential AH were evaluated. The patients were divided into two groups using the closed envelope method. The first group consisted of 34 patients, including 22 (64.7 %) women and 12 (35.3 %) men (mean age, 64.5±15.3), who received a fixed-dose combination of bisoprolol and amlodipine in the form of Concor AM. The second group consisted of 30 patients, including 18 (60 %) women and 12 (40 %) men (mean age, 65.8±11.5) who received a free combination of bisoprolol and amlodipine. Results. The Concor AM treatment (group 1) resulted in a smooth decrease of systolic and diastolic BP, which reached normal values at 14 days of treatment and remained at this level during the follow-up period (21 days). In group 2, these parameters reached normal values at 21 days of treatment. In two months, all patients of group 1 (34 patients) followed physician’s recommendations and took Concor AM as prescribed. In group 2, 28 of 30 patients (93 %) continued the treatment, and 20 (71 %) of them strictly adhered to the prescribed dosing while 8 (29 %) of them stopped taking one of the two drugs without permission. Conclusion. Administration of a fixed-dose combination of bisoprolol and amlodipine provides faster and optimum control of BP and enhances compliance with the treatment.
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Grigorjeva N. Yu., Kuznetsov A. N., Koroleva M. E. Comparative evaluation of compliance with therapy with fixed and non-fixed combinations of drugs for arterial hypertension. Russian Heart Journal. 2015;14 (4):231–234

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