2015


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2015/№4

Changes in fibrillar components of abdominal aortic extracellular matrix in modeling different forms of experimental chronic stress

Zhmaylova S. V.1, Veber V. R.1, Rubanova M. P.1, Gubskaya P. M.1, Karev V. E.2, Ataev I. A.1
1 - Federal State Budgetary Educational Institution of Higher Professional Education, "Yaroslav-the-Wise Novgorod State University", B. St. Peterburgskaya 41, Veliky Novgorod 173003
2 - Federal State Budgetary Institution, "Research Institute of Childhood Infections at the Federal Medico-Biological Agency", Professora Popova 9, St. Petersburg 197022

Keywords: abdominal aorta, intima-media, chronic stress, essential hypertension

DOI: 10.18087/rhj.2015.4.2089

Background. A major feature of essential hypertension is stress dependence associated with damage to conduit blood vessels, primarily, the aorta. Aim. To study changes in extracellular matrix fibrillar components (elastin and collagen) in the abdominal aortic media in experimental modeling of different forms of chronic stress. Materials and methods. Experiments were performed on Wistar male rats. Two forms of stress, chronic adrenergic stress (CAS) and chronic cholinergic stress (CCS), were modeled by intraperitoneal injections of epinephrine or proserin for two weeks. After completion of the experiments, fibrous alterations were analyzed in the wall of abdominal aorta. Results. Both CAS and CCS modeling was associated with pronounced alterations of abdominal aortic extracellular matrix. Abdominal aortic elastin content was decreased in both forms of chronic stress. After the experiment completion, elastin degradation continued both in CAS and CCS for a month. Fragmentation of elastic membranes, destruction of elastic bridges, and appearance of “voids” in the aortic elastic carcass were observed in both stress models. Considerable changes in the elastic carcass of abdominal aortic wall were associated with development of pronounced fibrous alterations in the aortic media. Furthermore in CCS, these fibrous alterations progressed even in a month after completion of the proserin treatment.
  1. Lacolley P., Regnault V. Basic principles and molecular determinants of arterial stiffness. In: Laurent S., Cockroft J. Central aortic blood pressure. – Paris: Les Laboratories Servier, 2008. – c 27–34.
  2. Серебров В. Ю., Акбашева О. Е., Канская Н. В., Позднякова И. А. Эластин артерий в норме и при патологии. Вопросы реконструкции и пластической хирургии. 2002;2 (3):54–8.
  3. Shadwick RE. Mechanical design in arteries. J Exp Biol. 1999 Dec;202 (Pt 23):3305–13.
  4. Avolio AP, Cben SG, Wang RP et al. Effects of aging on changing arterial compliance and left ventricular load in a northern Chinese urban community. Circulation. 1983 Jul;68 (1):50–8.
  5. Автандилов Г. Г. Медицинская морфометрия. Руководство. – М.: «Медицина», 1990. – c 204–205.
  6. Сматова М. Е. Строение стенок магистральных артерий при ограничении двигательной активности в условиях жаркого климата. Автореф. дис. … канд. мед. наук. – Санкт-Петербург, 2006.
Zhmaylova S. V., Veber V. R ., Rubanova M. P. et al. Changes in fibrillar components of abdominal aortic extracellular matrix in modeling different forms of experimental chronic stress. Russian Heart Journal. 2015;14 (4):242–247

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