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Blood levels of matrix metalloproteinase-9, tissue inhibitor of metalloproteases-1, and collagen biomarkers in patients with acute transmural myocardial infarction complicated with aneurysm

Govorin A. V., Ratsina E. V., Sokolova N. A., Fetisova N. V.
State Budgetary Educational Institution of Higher Professional Edication, "Chita State Medical Academy" of the RF Ministry of Health Care, Gorkogo 39a, Chita 672090, Transbaikalia Territory

Keywords: aneurysm, myocardial infarction, matrix metalloproteinases, prognosis

DOI: 10.18087/rhj.2015.1.2039

Background. Postinfarction aneurysm considerably aggravates HF and increases the risk for heart arrhythmias and thromboembolic complications. Aim. To study time-related changes in biomarkers for collagen synthesis (PICP) and degradation (CITP), matrix metalloproteinase-9 (MMP-9), and tissue inhibitor of metalloproteinases-1 (TIMP-1) in acute anterior transmural MI complicated with aneurysm. Materials and methods. We evaluated 46 patients with acute transmural anterior MI for whom time-related changes in ММР-9, TIMP-1, PICP, and CITP were studied. Results. In MI patients without aneurysm, MMP-9 was significantly increased to 229.8 ng / ml at 1–3 days, decreased at 10–12 days and increased again to 237.3 hg / ml at 18–22 days. In MI patients with aneurysm, MMP-9 was slightly increased at 1–3 and 10–12 days; a greater increase in MMP-9 to 159.2 ng / ml was observed only at 18–22 days. In MI complicated with aneurysm, CIPT was increased to 0.504 ng / ml at 1–3 days; then CIPT gradually decreased to 0.467 ng / ml at 10–12 days and to 0.448 ng / ml at 8–22 days. In MI patients without aneurysm, increases in CIPT were insignificant in all periods of the follow-up. In patients without aneurysm, PICP was increased to 61.4 ng / ml at 1–3 days and remained high throughout all follow-up periods. In MI with aneurysm, PICP was slightly increased during all follow-up periods. Conclusion. The data obtained suggest that degradation of connective tissue components possibly prevail over their synthesis, which may result in thinning and bulging of the LV wall in the infarct area.
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Govorin A. V., Ratsina E. V., Sokolova N. A. et al. Blood levels of matrix metalloproteinase-9, tissue inhibitor of metalloproteases-1, and collagen biomarkers in patients with acute transmural myocardial infarction complicated with aneurysm. Russian Heart Journal. 2015;14 (1):30–33

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