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Risk factors and clinico-hemodynamic parameters in middle-aged and elderly women with myocardial infarction

Zheltova I. N., Sukmanova I. A., Tanana O. S., Kharitonova Ya. E.
Territorial State Budgetary Institution of Health Care, "Altai Territory Cardiologic Dispensary", Malakhova 46, Barnaul, Altai Territory 656055

Keywords: women, myocardial infarction, elderly age, risk factors

DOI: 10.18087/rhj.2015.1.2016

Background. Interest to IHD patterns in women, which has been increasing in the recent decade, warrants further insight into risk factors (RFs) and features of MI clinical course in women of different age groups. Aim. To differentially evaluate RFs and clinico-hemodynamic parameters in middle-aged and elderly women with acute MI. Materials and methods. The study included 76 women with MI. Indices of lipid and carbohydrate metabolism and sex hormone levels were measured, and ECG, EchoCG, 24-h Holter ECG monitoring and coronary angiography were performed for all patients. Results. For middle-aged women, the most important MI RFs were smoking, abdominal obesity, arterial hypertension, disorders of lipid and carbohydrate metabolism, early menopause, and increased anxiety. For elderly women, MI RFs included abdominal obesity, arterial hypertension with LV hypertrophy, insulin resistance, disorders of lipid metabolism, hypodynamia, and depression. Middle-aged women had higher incidences of Killip stage II–IV acute HF, LV aneurism, and early post-infarction angina. Elderly women with acute MI had higher incidences of CHF and heart rhythm disorders.
  1. Anand SS, Islam S, Rosengren A et al. Risk factors for myocardial infarction in women and men: insights from the INTERHEART study. Eur Heart J. 2008 Apr;29 (7):932–40.
  2. Maas AH, Van Der Schouw YT, Regitz-Zagrosek V et al. Red alert for women's heart: the urgent need for more research and knowledge on cardiovascular disease in women. Eur Heart J. 2011 Jun;32 (11):1362–8.
  3. Квиткова Л. В., Еленская Т. С., Благовещенская О. П., Барбараш О. Л. Эволюция инсулинорезистентности на примере больных инфарктом миокарда с подъемом сегмента ST. Сибирский медицинский журнал. 2011;26 (4–2):161–5.
  4. Шамес А. Б. Ишемическая болезнь сердца у женщин. – М.: БИНОМ, 2013. – 176с.
  5. Третье универсальное определение инфаркта миокарда. Россий­ский кардиологический журнал. 2013;2 (100), приложение 1.
  6. Wilson PW, D’Agostino RB, Sullivan L et al. Overweight and obesity as determinant of cardiovascular rick the Framingham experience. Arch Intern Med. 2002 Sep 9;162 (16):1867–72.
  7. Iglesias Bolaños P, Olivar Roldán J, Penalver Talavera D et al. Effect of abdominal obesity on size of myocardial infarction. Endocrinol Nutr. 2009 Jan;56 (1):4–8.
  8. Bouzas-Mosquera A, Broullón FJ, Alvarez-Garcia N et al. Associ­ation of left ventricular mass with all-cause mortality, myocardial infarction and stroke. PLoS One. 2012 Sep 26;7 (9):e45570.
  9. Tan YY, Gast GC, van der Schouw YT. Gender differences in risk factors for coronary heart disease. Maturitas. 2010 Feb;65 (2):149–60.
  10. Robins SJ, Lyass A, Zachariah JP et al. Insulin resistance and the relationship of a dyslipidemia to coronary heart disease: the Framingham Heart Study. Arterioscler Thromb Vasc Biol. 2011 May;31 (5):1208–14.
  11. Salehi R, Motemavele M, Goldust M. Rick factors of coronary disease in women. Pak J Biol Sci. 2013;16 (4):195–7.
  12. Reslan OM, Khalil RA. Vascular effects of estrogenic menopausal hormone therapy. Rev Recent Clin Trials. 2012 Feb;7 (1):47–70.
  13. Shaw LJ, Bugiardini R, Merz CN. Women and ischemic heart disease: evolution knowledge. J Am Coll Cardiol. 2009 Oct 20;54 (17):1561–75.
  14. Васюк Ю. А., Довженко Т. В., Семиглазова М. В., Краснов В. Н. Тревожно-депрессивные расстройства и сердечно-сосудистые заболевания: клинические взаимосвязи и современные подходы к терапии. Сердце. 2012;11 (3):155–64.
  15. Smolderen KG, Spertus JA, Reid KJ et al. Association of somatic and cognitive depressive symptoms and biomarkers in acute myocardial infarction: insights from the TRIUMPH Registry. Biol Psychiatry. 2012 Jan 1;71 (1):22–9.
  16. Bekke-Hansen S, Trockel M, Burg MM, Taylor CB. Depressive symptom dimensions and cardiac prognosis following myocardial infarction: results from the ENRICHD clinical trial. Psychol Med. 2012 Jan;42 (1):51–60.
  17. Frasure-Smith N, Lespérance F. Depression and cardiac risk: pre­sent status and future directions. Heart. 2010 Feb;96 (3):173–6.
  18. Волчкова Н. С., Субханкулова С. Ф. Профилактика сердечно-сосудистых заболеваний. Вестник современной клинической медицины. 2009;2 (4):25–30.
  19. Терещенко С. Н., Жиров И. В. Депрессия после инфаркта миокарда: угроза или гибель? Кардиология. 2007;47 (8):93–6.
Zheltova I. N., Sukmanova I. A., Tanana O. S. et al. Risk factors and clinico-hemodynamic parameters in middle-aged and elderly women with myocardial infarction. Russian Heart Journal. 2015;14 (1):8–12

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