2015


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2015/№1

Effects of myocardial cytoprotection and inotropic stimulation on one-year prediction in patients with ST segment elevation myocardial infarction complicated with heart failure

Sinkova M. N.1, Isakov L. K.1, Vatutin M. K.1, Pepelyaeva T. V.2, Tarasov N. I.1, Teplyakov A. T.3
1 - State Budgetary Educational Institution of Higher Professional Education, "Kemerovo State Medical Academy" of the RF Ministry of Health Care, Voroshilova 22a, Kemerovo 650029
2 - Federal Government Institution of Health Care, "Medical Sanitary Unit of the RF Ministry of Internal Affairs for the Kemerovo Region", Kuzbasskaya 10a, Kemerovo 650099
3 - Federal State Budgetary Institution, "Research Institute of Cardiology" at the Siberian Division of the Russian Academy of Medical Sciences, Kievskaya 111a, Tomsk 634012

Keywords: ST-segment elevation myocardial infarction, heart failure, cytoprotective therapy

DOI: 10.18087/rhj.2015.1.1995

Background. Convincing evidence for efficacy and safety of the cytoprotector and inotropic stimulator combination treatment in acute MI complicated with HF is presently unavailable. Aim. To evaluate the effect of meldonium dihydrate and levosimendan on the one-year prediction in patients with MI complicated with Killip class II–III acute HF, after transcutaneous transluminal coronary angioplasty. Materials and methods. The study included 130 patients with ST segment elevation MI and Killip class II–III HF who were admitted within the first 12 hours of the disease onset. Patients were randomized to four groups. Group A consisted of patients receiving a standard multimodality therapy; Group B included patients receiving the standard therapy plus the meldonium dehydrate treatment. Group C consisted of patients receiving the standard therapy plus the levosimendan treatment. Group D received the standard therapy plus the meldonium dehydrate treatment and the levosimendan treatment. Results. In Group D at the end of 12‑months follow-up, LV EF was increased, the reinfarction rate was decreased, and the rate of readmission for progression of IHD and HF was decreased. Conclusion. The combination treatment with meldonium dehydrate and levosimendan improved both intracardiac hemodynamics and the one-year prediction.
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Sinkova M. N., Isakov L. K., Vatutin M. K. et al. Effects of myocardial cytoprotection and inotropic stimulation on one-year prediction in patients with ST segment elevation myocardial infarction complicated with heart failure. Russian Heart Journal. 2015;14 (1):25–29

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