2014


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2014/№4

Heart rhythm variability in patients with essential hypertension after acute cerebrovascular disease

Polupanov A.G., Dzhumagulova A.S., Romanova T.A., Cheskidova N.B.

Keywords: heart rate variability, ischemic stroke, tilt test, essential hypertension

DOI: 10.18087/rhj.2014.4.1945

Background. Inconsistent results from studies of heart rhythm variability (HRV) in hypertensive patients, especially with regard to the range of HRV spectrum low-frequency component, determine the topicality of studies in this field. Aim. To study HRV in patients with essential hypertension (EH) after acute cerebrovascular disease. Materials and methods. We studied HRV in 16 EH patients who had had ischemic stroke 0.5–3 years before the enrollment in the study. Control group included 53 patients with uncomplicated EH (without stroke and myocardial disease, i.e., LV hypertrophy). HRV was assessed using the Holter ECG monitoring system “Memoport 2000”. Results. Evaluation of the autonomic nervous system (ANS) in EH patients after ischemic stroke detected significant decreases in the power of all HRV spectral characteristics (TP, VLF, LF, HF). In this group of patients, the tilt test reduced power of the LF component, which suggested a disadaptive (abnormal) response to verticalization of the ANS sympathetic part. Conclusion. The disadaptive response of LF component to the orthostatic test may represent a prognostically unfavorable sign of developing cerebrovascular complications in EH patients.
  1. Кыргызстан в цифрах. Национальный статистический комитет Кыргызской Республики. – Бишкек, 2008. – 335 с.
  2. Фонякин А. В., Гераскина Л. А., Домашенко М. А. Вариабельность сердечного ритма при ишемическом инсульте. Вестник аритмологии 2005. Доступно на: www//incart.spb.ru / vestnic / n35 / tezis95.htm.
  3. Negrusz-Kawecka M, Kobusiak-Prokopowicz M. Studies of arrhy­thmia incidence and heart rate variability in patients suffering from cerebral stroke. PolArchMedWewn. 1998 Dec;100 (6):515–525.
  4. Bassi A, Colivicchi F, Santini M, Caltagirone C. Gender-specific predictors of functional outcome after stroke rehabilitation: potential role of the autonomic nervous system. Eur Neurol. 2010;63 (5):279–84.
  5. Orlandi G, Fanucchi S, Strata G et al. Transient autonomic nervous system dysfunction during hyperacute stroke.ActaNeurol Scand. 2000 Nov 102 (5):317–321.
  6. Kario K, Motai K, Mitsuhashi T et al. Autonomic nervous system dysfunction in elderly hypertensive patients with abnormal diurnal blood pressure variation: relation to silent cerebrovascular disease. Hypertension. 1997 Dec 30 (6):1504–1510.
  7. Chen CF, Lai CL, Lin HF et al. Reappraisal of heart rate variabi­lity in acute ischemic stroke. Kaohsiung J Med Sci. 2011 Jun 27 (6):215–21.
  8. Chen CF, Lin HF, Lin RT et al. Relationship between ischemic stroke location and autonomic cardiac function. J Clin Neurosci. 2013 Mar 20 (3):406–9.
  9. Huang SS, Su HH, Kuo TB et al. Suppressing cardiac vagal modu­lation and changing sleep patterns in rats after chronic ischemic stroke injury. Auton Neurosci. 2012 Aug 16;169 (2):116–23.
  10. Xiong L, Leung HW, Chen XY et al. Autonomic dysfunction in different subtypes of post-acute ischemic stroke. J Neurol Sci. 2014 Feb 15;337 (1-2):141–6.
  11. Graff B, Gąsecki D, Rojek A et al. Heart rate variability and functional outcome in ischemic stroke: a multiparameter approach. J Hypertens. 2013 Aug 31 (8):1629–36.
  12. Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Eur Heart J. 1996;17 (3):354–381.
  13. Тарасова О. С., Мартьянова А. А., Родионов И. М. Роль медиаторов в регуляции артериального давления. Природа. 2001;11:21–27.
  14. Родионов И. М., Косяков А. Н., Тарасова О. С. и др. Бюл. эксперим. биол. и медицины. 1995;11:461–464.
  15. Günther A, Salzmann I, Nowack S et al. Heart rate variability – a potential early marker of sub-acute post-stroke infections. Acta Neurol Scand. 2012 Sep 126 (3):189–96.
Polupanov A.G., Dzhumagulova A.S., Romanova T.A. et al. Heart rhythm variability in patients with essential hypertension after acute cerebrovascular disease. Russian Heart Journal. 2014;78 (4):256–260

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