2014


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2014/№3

A method for evaluating a probability of coronary rethrombosis in patients with ST-segment elevation acute coronary syndrome at the stage of reperfusion drug therapy

Mitkovskaya N.P., Abelskaya I.S., Statkevich T.V., Balysh E.M., Pateyuk I.V., Grigorenko E.A., Medvedev D.G., Bosyakov S.M.

Keywords: CAD, treatment, ACS, thrombosis

DOI: 10.18087/rhj.2014.3.1924

Background. Rethrombosis of an infarct-related coronary artery following successful thrombolytic therapy (TLT) occurs in approximately 8–12 % of cases in the first 2–3 weeks and in 15–25 % of cases within one year, which significantly worsens the prognosis. Aim. To develop a method for evaluating the probability of coronary rethrombosis in patients with ST-elevation ACS at the stage of reperfusion drug therapy. Materials and methods. 115 patients (aged 35–78) with ST-elevation ACS were evaluated after effective thrombolytic therapy. Clinical, instrumental, laboratory and statistical study methods were used. Results. A computer program was developed for prediction of rethrombosis in patients with ST-elevation ACS at the stage of reperfusion drug therapy.
  1. Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC). ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J. 2012 Oct;33 (20):2569–619.
  2. De Luca G, Suryapranata H, Marino P. Primary angioplasty vs. thrombolysis. Indian Heart J. 2007 Jul-Aug;59 (4):302–10.
  3. De Luca G, Cassetti E, Marino P. Percutaneous coronary intervention-related time delay, patient's risk profile, and survival benefits of primary angioplasty vs lytic therapy in ST-segment elevation myocardial infarction. Am J Emerg Med. 2009 Jul;27 (6):712–9.
  4. Boersma E1; Primary Coronary Angioplasty vs. Thrombolysis Group. Does time matter? A pooled analysis of randomized clinical trials comparing primary percutaneous coronary intervention and in-hospital fibrinolysis in acute myocardial infarction patients. Eur Heart J. 2006 Apr;27 (7):779–88.
  5. Fernández-Avilés F1, Alonso JJ, Peña G et al. Primary angioplasty vs. early routine post-fibrinolysis angioplasty for acute myocardial infarction with ST-segment elevation: the GRACIA-2 non-inferiority, randomized, controlled trial. Eur Heart J. 2007 Apr;28 (8):949–60.
  6. De Luca G1, Cassetti E, Marino P. Percutaneous coronary intervention-related time delay, patient's risk profile, and survival benefits of primary angioplasty vs lytic therapy in ST-segment elevation myocardial infarction. Am J Emerg Med. 2009 Jul;27 (6):712–9.
  7. Khan IA, Gowda RM. Clinical perspectives and therapeutics of thrombolysis. Int J Cardiol. 2003 Oct;91 (2-3):115–27.
  8. Hudson MP1, Granger CB, Topol EJ et al. Early reinfarction after fibrinolysis: experience from the global utilization of streptokinase and tissue plasminogen activator (alteplase) for occluded coronary arteries (GUSTO I) and global use of strategies to open occluded coronary arteries (GUSTO III) trials. Circulation. 2001 Sep 11;104 (11):1229–35.
Mitkovskaya N.P., Abelskaya I.S., Statkevich T.V. et al. A method for evaluating a probability of coronary rethrombosis in patients with ST-segment elevation acute coronary syndrome at the stage of reperfusion drug therapy. Russian Heart Journal. 2014;77 (3):136–143

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