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Circulating endothelial progenitor cells and complications of cardiovascular diseases: Role of angiotensin converting enzyme inhibitors

Gilyarevsky S. R., Golshmid M. V., Kuzmina I. M.

Keywords: ACE inhibitors, treatment, perindopril, cardiovascular diseases

DOI: 10.18087/rhj.2013.5.1877

Cell therapy is a promising approach to enhanced treatment of patients with complicated CVD. However at the present time, such therapy cannot be considered routine due to limited evidence database and some ambiguity in methods of practical implementation. In these conditions, of special interest are the data obtained on animal models demonstrating a possibility for increasing the number of endothelial progenitor cells (EPC) and for improving their function by using ACE inhibitors, specifically perindopril. The obtained data can additionally justify the use of ACE inhibitors as first-line drugs for prevention of CVD complications in a large patient contingent.
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Gilyarevsky S.R., Golshmid M.V., Kuzmina I.M. Circulating endothelial progenitor cells and complications of cardiovascular diseases: Role of angiotensin converting enzyme inhibitors. Russian Heart Journal. 2013;12(5):267-272

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