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Effect of acetylsalicylic acid formulations on morpho-functional status of gastric mucosa in elderly cardac patients

Yakovenko E. P., Krasnolobova L. P., Yakovenko A. V., Agafonova N. A., Ivanov A. N., Bogomolova E. A., Pavlova Yu. Yu., Pryanishnikova A. S.

Keywords: acetylsalicylic acid, gastric secretion in elderly, intragastric рH-metry, cardiomagnyl, NSAID-associated gastropathy

DOI: 10.18087/rhj.2013.3.1827

Background. Administration of acetylsalicylic acid (ASA) is associated with gastrointestinal side effects including primarily dyspeptic disorders and erosive and ulcerative lesions. Aim. Comparing effects of two ASA formulations, enteric coated tablets (Trombo ASS 100 mg) and Cardiomagnyl tablets (ASA 150 mg + magnesium hydroxide 30.4 mg) containing the non-absorbable antacid magnesium hydroxide, on the morphological and functional state of gastric mucosa in patients with cardiovascular disease. Materials and methods. The condition of gastroduodenal area and stomach acid production as well as effects of single-dose medicine on intragastric pH were studied in 132 cardiac patients chronically taking Trombo ASS 100 mg or Cardiomagnyl 150 mg. Results. The ASA treatment was associated with predominating erythematous and hemorrhagic type of NSAID gastropathy which was significantly rarer in patients taking Cardiomagnyl. 70 % of patients older than 60 years had normal or increased gastric acid production, a factor of gastropathy development. Single-dose administration of Cardiomagnyl lowered intragastric acidity in patients with normal or reduced stomach acid production.
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Yakovenko E. P., Krasnolobova L. P., Yakovenko A. V. et al. Effect of acetylsalicylic acid formulations on morpho-functional status of gastric mucosa in elderly cardac patients. Russian Heart Journal. 2013;12(3):148-153

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