Genotypic traits of renin-angiotensin system in hypertensive patients of the populations in the Republic of Mordovia
Arutiunov G. P., Goncharova L. N., Postnov A. Yu.
Keywords: hyperpiesis, ethnic origin, angiotensin-converting enzyme gene polymorphism, АТ2R1 polymorphism
Relevance. Hypertension is one of the leading factors of mortality in the Republic of Mordovia. This is why studying of the genetic reasons causing development of this disease is relevant. Objective. Study distribution of insertion-deletion I / D polymorphism of ACE gene and А1166С polymorphism of АТ2R1 gene in patients with proved hypertension of Mordovian (Moksha, Erzya) and Russian ethnicities, who reside in Mordovia and are native to this area within three generations. Materials and methods. 291 patient with essential hypertension and 117 non-hypertensive volunteers of Russian and Mordovian (Mordva-Moksha and Mordva-Erzya) ethnicities. The method of polymerase chain reaction studies distribution of insertion-deletion polymorphism of I / D of angiotensin-converting enzyme gene and А1166С polymorphism of АТ2R1 gene depending on ethnical identity and gender. Results and conclusion. Polyspecificity of “adverse” DD genotype of ACE gene carrier state was revealed in male Mordva-Moksha hypertensive patients. High risk of hypertension in Mordva-Moksha normotensive women was noted, which exceeds hypertension risk in Russian and Mordva-Erzya normotensive women. The analysis of АТ2R1 polymorphism showed that, irrespective of ethnicity, gender, and BP level, favorable АА genotype prevails in hypertensive patients.
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Arutiunov G. P., Goncharova L. N., Postnov A. Yu. Genotypic traits of renin-angiotensin system in hypertensive patients of the populations in the Republic of Mordovia. Russian Heart Journal. 2013;12(2):112-118