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Predictors of immediate and long-term adverse outcomes of acute coronary syndrome (retrospective study)

Kurochkina O. N., Khokhlov A. L., Spasskiy A. A., Bogomolov A. N.

Keywords: patient survival rate, myocardial infarction, prognostic factors, thrombolytic therapy, pharmacoepidemiolog

DOI: 10.18087/rhj.2013.1.1728

Relevance. According to some authors, female patients are noted by higher hospital and long-term lethality after MI in comparison with male patients. The results of other studies evidence that gender is not an independent predictor of death rate after MI. Objective. Define factors of hospital and long-term lethality of male and female MI patients. Materials and methods. Case records of the patients who suffered MI were selected by the continuous method. The survival rate of patients within 8 years after MI was followed according to statistic data. Data of the total of about 778 MI patients was analyzed, female – 46.3 %, average age 63.7±12.8 years. Binary logistical regression was carried out to reveal independent factors connected with development of lethal outcome; Kaplan-Meier method and Cox proportional regression model were used to evaluate the remote survival rate of patients with previous MI. Results. ACE inhibitors were prescribed, thrombolytic therapy and transcutaneous coronary intervention were performed less often to female patients; they were prescribed more often with diuretics and antiarrhythmic agents. Increased risk of the hospital and long-term lethality in comparison with male were not revealed in female patients. The greatest prognostic significance concerning MI adverse outcome, irrespective of patient’s gender, is attributed to the following factors: age, MI severity, expressiveness of renal dysfunction; during the acute MI period. Besides the above factors, adverse effect on survival rate of hyperglycemia and protective role of previous hypertension was established.
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Kurochkina O. N., Khokhlov A. L., Spasskiy A. A. et al. Predictors of immediate and long-term adverse outcomes of acute coronary syndrome (retrospective study). Russian Heart Journal. 2013;12(1):28-32

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