2012


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2012/№6

New fixed combination of ACE inhibitors and calcium antagonist in treatment of arterial hypertension in patients with diabetes mellitus type 2

Smolenskaya O. G., Vedenskaya S. S.

Keywords: calcium antagonists, hyperpiesis, ace inhibitors, treatment, microalbuminuria, type 2 diabetes mellitus

DOI: 10.18087 / rhj.2012.6.1746

Relevance. While choosing antihypertensive therapy in patients with DM type 2, a lot of features are should be considered. These are: prolong hypotensive effect, notable organ-protection and metabolic neutrality concerning carbohydrate and lipid metabolism. Objective. Evaluate antihypertensive efficacy of the fixed combination of perindopril arginin / amlodipine (Prestranse) and its influence on urine albumin levels in patients with DM 2 типа and hypertension within 12 weeks of active treatment. Materials and methods. 20 patients with hypertension and DM type 2 were enrolled. Before and after treatment by the fixed combination of perindopril / amlodipine. BP control and urine albumin level evaluation was carried out. Depending on BP level, the combination of perindopril arginin / amlodipine was administered in the following doses 5 / 5 mg, 10 / 5, 5 / 10, 10 / 10 mg. Results and conclusion. High antihypertensive efficacy of the fixed combination of perindopril / amlodipine was noted, achievement of target BP values in 70 % of patients. The antihypertensive therapy promoted some reduction of urine albumins in patients with normal albuminuria.
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Smolenskaya O. G., Vedenskaya S. S. New fixed combination of ACE inhibitors and calcium antagonist in treatment of arterial hypertension in patients with diabetes mellitus type 2. Russian Heart Journal. 2012;11(6):337-341.

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