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New pharmacological strategies of atrial fibrillation treatment: accent on atrial selectivity (part II)

Tatarskiy B. A., Biserova I. N.
Federal State Budgetary Institution, “North-West Federal Medical Research Center” of the RF Ministry of Health Care, Akkuratova 2, St.-Petersburg 197341

Keywords: treatment, atrial selectivity, atrial fibrillation

DOI: 10.18087/rhj.2012.6.1735

The review covers experimental and clinical studies atrium-specific and predominant drugs for treatment of atrial fibrillation (AF). It was shown that the main strategy of arrhythmia suppression and sinus rhythm maintenance remains ion channel inhibition. We assume that drugs blocking several ion channels are more effective for rhythm control than selective blockers. The provided results of the studies carried out indicate that simultaneous blockade fast sodium, potassium and slow sodium channels can be accompanied by selective atrial effect with very low risk of induction ventricular tachycardia.
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Tatarskiy B. A., Biserova I. N. New pharmacological strategies of atrial fibrillation treatment: accent on atrial selectivity (part II). Russian Heart Journal. 2012;11(6):369-375.

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