2012


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2012/№5

Use of carvedilol in treatment of arterial hypertension

Parnes E. Ya.

Keywords: hyperpiesis, beta-adrenergic blocker agents, carvedilol

DOI: 10.18087 / rhj.2012.5.1713

Results of the meta-analyses assessing efficiency of beta-blockers in treatment of noncomplicated AH, evidence their lesser efficiency than that of ACE inhibitors, angiotensin II receptor blockers, calcium-channel blockers and diuretics. The overwhelming majority of the studies were carried out with use atenolol and metoprolol tartrate, though. Carvedilol, even being a beta-blocker, does not has many adverse properties of drugs of this group: it does not cause increase of peripheral resistance, does not raise central aortic pressure, does not promote increase of blood glucose level, does not raise thyroglobulin level and total cholesterol in blood, does not cause expressed negative chronotropic effect, which is why is easier tolerated, including by elderly patients. On the other hand, carvedilol has many positive effects, which are not typical for previous generations beta-blockers. Among them: positive effects on endothelium dysfunction, improving of central haemodynamics, LV hypertrophy regression, reducing of vascular wall rigidity, coronary reserve increase, cardio- and nephroprotective action, positive impact on insulin resistance, antioxidative, anti-inflammatory and antiproliferative effects., Taking into account absence of the influence on carbohydrate and lipid exchanges, Carvedilol can be used in persons with metabolic syndrome, DM type 2, and in patients with peripheral artery diseases.
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Parnes E. Ya. Use of carvedilol in treatment of arterial hypertension. Russian Heart Journal. 2012;11(5):309-317.

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