Use of Bivalirudin at performance of percutaneous coronary intervention in patients with acute coronary syndrome
Movsesiants M. Yu., Mironkov A. B., Maltsev A. V., Kiselev D. G., Abugov S. A.
Keywords: bivalirudin, myocardial infarction, acute coronary syndrome, transcutaneous coronary intervention
DOI: 10.18087 / rhj.2012.5.1706
At carrying out of percutaneous coronary intervention (PCI) in patients with ACS, antiplatelet and anticoagulant therapies are very important. Administration of indirect thrombin inhibitors – unfractionated or low molecular weight heparins in combination with aspirin, clopidogrel, and, sometimes, with platelet glycoprotein IIb / IIIa receptors blockers – at carrying out of PCI in patients with ACS is connected with high risk of bleedings. A new anticoagulant, which belongs to the class of direct thrombin inhibitor, Bivalirudin has been introduced to the clinical practice. The properties of this drug are not inferior to that of indirect thrombin inhibitors in prevention of adverse heart events, but the results of its administration demonstrate a considerable decrease in bleedings in patients with ACS who undergo PCI. This article reviews researches and first experience of administration of this drug in patients with ST segment elevation MI and non-ST segment elevation ACS at PCI.
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Movsesiants M. Yu., Mironkov A. B., Maltsev A. V. et al. Use of Bivalirudin at performance of percutaneous coronary intervention in patients with acute coronary syndrome. Russian Heart Journal. 2012;11(5):259-263.