Omega-3 index and its interrelation with sudden coronary death predictors in patients related with coronary heart disease and ventricular rhythm disturbances
Gavva E. M., Tsaregorodtsev D. А., Mamedov I. S., Sulimov V. А.
Keywords: sudden coronary death, coronary heart disease, heart rhythm disturbances, omega-3 fatty acids
DOI: 10.18087 / rhj.2012.2.1675
Relevance. Stratification of sudden coronary death (SCD) risk remains an urgent problem of modern cardiology. Omega-3 index is considered as a SCD predictor. Objective. Estimate interrelation between omega-3 index and demographic, electrophysiological and EchoCG predictors of SCD in patients with CHD and ventricular rhythm disturbances. Materials and methods. The study included 25 CHD patients with ventricular disturbances of heart rhythm. Percentage of erythrocyte EPA, DHA and their sum (omega-3 index) in erythrocytes of the peripheral blood was defined. 24‑hour monitoring of ECG and EchoCG was carried out. Results. Values of patients’ erythrocyte omega-3 index fluctuated from 1.12 to 6.4 %. Poor direct correlation between erythrocyte omega-3 index, EPA percentage, and heart rhythm variability index pNN50, and feedback between omega-3 index and DHA percentage with number of ventricular extrasystoles (VE) within 24 hours was revealed. mTWA value at 5 p.m. estimated in the second monitor lead at ⅛ actualization factor was characterized by poor positive relation with omega-3 index and DHA. The relation of the maximum rates early and late LV diastolic filling (Е / А) was characterized by direct relation of average force with omega-3 index, EPA and DHA contents. Conclusion. Patients with CHD and ventricular disturbances of heart rhythm are characterized by low omega-3 index of erythrocytes corresponding high (56 %) and average (44 %) risk of cardiovascular complications. Omega-3 index of erythrocytes has inverse correlation with 24‑hour number of VEs and direct correlation – with HRV index (pNN50) and Е / А relation.
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Gavva E. M., Tsaregorodtsev D. А., Mamedov I. S., Sulimov V. А. Omega-3 index and its interrelation with sudden coronary death predictors in patients related with coronary heart disease and ventricular rhythm disturbances. Russian Heart Journal. 2012;11(2):89-93