2012


To access this material please log in or register

Register Authorize
2012/№2

Monotherapy of hypertension: a dethronement of myths

Nedogoda S. V.

Keywords: hypertension, therapy

DOI: 10.18087/rhj.2012.2.1673

Early combined therapy has been recently administered more and more often to treat hypertension. Without disputing its necessity and reasonability, it is still necessary to define exactly a circle of patients who need monotherapy, because redundant treatment is as dangerous as inefficient therapy. Monotherapy seems to be overgrown with some firm myths that make for a negative attitude to of the medical community.
  1. Corrao G, Nicotra F, Parodi A et al. Cardiovascular protection by initial and subsequent combination of antihypertensive drugs in daily life practice. Hypertension. 2011;58 (4):566–572.
  2. Houlihan SJ, Simpson SH, Cave AJ et al. Hypertension treatment and control rates: chart review in an academic family medicine clinic. Can Fam Physician. 2009;55 (7):735–741.
  3. Chobanian AV. Major improvements in the control of hypertension in Canada. CMAJ. 2011;183 (9):996–997.
  4. McAlister FA, Wilkins K, Joffres M et al. Changes in the rates of awareness, treatment and control of hypertension in Canada over the past two decades. CMAJ. 2011;183 (9):1007–1013.
  5. McAlister FA, Campbell NR, Duong-Hua M et al. Antihypertensive medication prescribing in 27,822 elderly Canadians with diabetes over the past decade. Diabetes Care. 2006;29 (4):836–841.
  6. Khan NA, Yun L, Humphries K, Kapral M. Antihypertensive drug use and adherence after stroke: are there sex differences? Stroke. 2010;41 (7):1445–1449.
  7. The impact of initial treatment of hypertension on control in the first year: Comparison of initial monotherapy, free-dose combination, and fixed-dose combinations. ASH 2011; Abstract PO-142. Available at: http://www.ash-us.org / documents / ASH-2011‑Achievements-in-Hypertension-Control-110522.pdf
  8. Шальнова С. А., Деев А. Д., Вихирева О. В. и соавт. Распространенность артериальной гипертонии в России: информированность, лечение, контроль. Профилактика заболеваний и укрепление здоровья. 2001;2:3–7.
  9. Baguet JP, Robitail S, Boyer L et al. A meta-analytical approach to the efficacy of antihypertensive drugs in reducing blood pressure. Am J Cardiovasc Drugs. 2005;5 (2):131–140.
  10. Greathouse M. Olmesartan medoxomil combined with hydrochlorothiazide for the treatment of hypertension. Vasc Health Risk Manag. 2006;2 (4):401–409.
  11. Preston RA, Materson BJ, Reda DJ, Williams DW. Placebo-associated blood pressure response and adverse effects in the treatment of hypertension: observations from a Department of Veterans Affairs Cooperative Study. Arch Intern Med. 2000;160 (10):1449–1454.
  12. Hurst M, Jarvis B. Perindopril. Perindopril: an updated review of its use in hypertension. Drugs. 2001;61 (6):867–896.
  13. Недогода С. В. Монотерапия артериальной гипертензии: конец главы или продолжение следует? Consilium medicum. 2011;13 (1):3–11.
  14. Julius S, Kjeldsen SE, Brunner H et al. VALUE trial: Long-term blood pressure trends in 13,449 patients with hypertension and high cardiovascular risk. Am J Hypertens. 2003;16 (7):544–548.
  15. Mourad JJ, Le Jeune S. Evaluation of high dose of perindopril / indapamide fixed combination in reducing blood pressure and improving end-organ protection in hypertensive patients. Curr Med Res Opin. 2009;25 (9):2271–2280.
  16. Синицин В. Е., Стукалова О. В., Чазова И. Е. и др. Влияние длительной терапии комбинацией лозартана и гидрохлоротиазида на суточный профиль артериального давления и гипертрофию левого желудочка у больных с мягкой и умеренной артериальной гипертонией. Кардиология 2003;53 (10):60–65.
  17. Aepfelbacher FC, Messerli FH, Nunez E, Michalewicz L. Cardiovascular effects of a trandolapril / verapamil combination in patients with mild to moderate essential hypertension. Am J Cardiol. 1997;79 (6):826–828.
  18. Mazerska M, Rydzewski A, Poplawska A et al. Effects of antihypertensive treatment on microalbuminuria and fibrinolytic activity in type II diabetic patients. Fibrinolysis. 1996;10 (Suppl 3):123.
  19. Fogari R, Derosa G, Zoppi A et al. Effect of telmisartan-amlodipine combination at different doses on urinary albumin excretion in hypertensive diabetic patients with microalbuminuria. Am J Hypertens. 2007;20 (4):417–422.
  20. Hayakawa H, Coffee K, Raij L. Endothelial dysfunction and cardiorenal injury in experimental salt-sensitive hypertension: effect of antihypertensive therapy. Circulation. 1997;96 (7):2407–2413.
  21. Schneider M, Lerch M, Papiri M et al. Metabolic neutrality of combined verapamil-trandolapril treatment in contrast to beta-blocker-low-dose chlortalidone treatment in hypertensive type 2 diabetes. J Hypertens. 1996;14 (5):669–677.
  22. Zanchetti A. Blood pressure targets of antihypertensive treatment: up and down the J-shaped curve. Eur Heart J. 2010;31 (23):2837–2840.
  23. Grundvold I, Skretteberg PT, Liestøl K et al. Upper normal blood pressures predict incident atrial fibrillation in healthy middle-aged men: a 35‑year follow-up study. Hypertension. 2012;59 (2):198–204.
  24. Lee M, Saver JL, Chang B et al. Presence of baseline prehypertension and risk of incident stroke: a meta-analysis. Neurology. 2011;77 (14):1330–1337.
  25. Raise a red flag – prehypertension and prediabetes together boost CVD risk. Available at: http://www.hiirc.org.nz / page / 17803 / raise-a-red-flag-prehypertension-and-prediabetes / ?contentType=251&section=10790
  26. Thompson AM, Hu T, Eshelbrenner CL et al. Antihypertensive treatment and secondary prevention of cardiovascular disease events among persons without hypertension: a meta-analysis. JAMA. 2011;305 (9):913–922.
  27. Towfighi A, Kelley G. The (pre) hypertension limbo: Is it time to lower the treatment bar? Neurology. 2011;77 (14):1322–1323.
  28. Ventura HO, Lavie CJ. Antihypertensive therapy for prehypertension: relationship with cardiovascular outcomes. JAMA. 2011;305 (9):940–941.
  29. Verdecchia P, Mazzotta G, Angeli F, Reboldi G. Above which blood pressure level does the risk of atrial fibrillation increase? Hypertension. 2012;59 (2):184–185.
  30. Julius S, Nesbitt S, Egan B, Eric Michelson E. Trial Of Preventing Hypertension: Main results. ACC.06, the 55th Annual Scientific Session of the American College of Cardiology. Late Breaking Clinical Trials, Tuesday, March 14, 2006. Abstract 418–419.
Nedogoda S. V. Monotherapy of hypertension: a dethronement of myths. Russian Heart Journal. 2012;11(2):108-111

To access this material please log in or register

Register Authorize
Ru En