2004


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2004/№3

Study on the cerebroprotective efficacy of long-term antihypertensive therapy

Mordovin V.F., Afanasieva N.L., Kolodina M.V., Lukjyanenok P.I., Semke G.V., Belokopytova N.V., Karpov R.S.

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Study focused on the effect of long-term antihypertensive therapy on cerebral alterations in patients with essential
hypertension (EH). All patients underwent the 24-h blood pressure (BP) monitoring and brain magnetic-resonance (MR) tomography at baseline and then after 6 months of treatment. After the 6-month treatment with different classes of antihypertensive drugs (indapamid retard, enalapril, nifedipin), brain MR tomography revealed decreases in linear brain dimensions, subarachnoidal spaces and brain cisterns. The most pronounced positive dynamics was observed with the indapamid treatment. Data obtained suggest that long-term, controlled treatment of essential hypertension is associated with decreased pronouncement of structural alterations in the brain characteristic of hypertensive encephalopathy.

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