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New possibilities of diagnostics and control of efficacy of drug therapy for chronic heart failure

Gyamdzhyan K. A., Kukes V. G.
Federal State Budgetary Educational Institution of Higher Education "I. M. Sechenov First Moscow State Medical University" of the Ministry of Health of the Russian Federation, Trubetskaya 8, Bldg. 2, Moscow 119991

Keywords: chronic heart failure, efficacy of drug therapy, galectin-3

DOI: 10.18087/rhfj.2017.3.2360

Background. Development of new biomarkers, which could be used as instruments for early detection of diseases to select drug therapy and monitor its efficacy, remains relevant. Aim. To assess the clinical value of measuring galectin-3 in patients with chronic heart failure. Materials and methods. The study included 53 patients (31 women and 22 men) with NYHA FC II-III CHF. Mean age of patients was 71 (95% CI, 68.99-74.37). The NYHA FC II CHF group consisted of 14 patients and the NYHA FC II CHF group consisted of 39 patients. Median baseline NT-proBNP level was 65.7 pmol/l and median baseline galectin-3 level was 8.37 pmol/l. Results. Increased galectin-3 levels correlated with reduced EF% (r=-0.26; p=0.04), increased creatinine (r=0.26, p=0.04), and increased plasma NT-proBNP (r=0.3; p=0.02). No significant correlation was found with other clinical indexes, such as systolic BP, diastolic BP, heart rate, BMI, 6-min walk test, left ventricular myocardial mass index, glucose concentration, total cholesterol, and GFR. A moderate correlation was observed for levels of NT-proBNP and plasma galectin-3 (r=0.3; p=0.02). Post-treatment decreases in galectin-3 were observed in 84.3% patients. Conclusion. Galectin-3 can be used as an auxiliary diagnostic biomarker for CHF.
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Gyamdzhyan K. A., Kukes V. G. New possibilities of diagnostics and control of efficacy of drug therapy for chronic heart failure. Russian Heart Failure Journal. 2017;18(3):185–189

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