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2017/№3

Cell therapy for dilated cardiomyopathy: State-of-the-art

Safiullina A. A., Uskach T. M., Tereshchenko S. N., Zhirov I. V.
Federal State Budgetary Institution, "Russian Cardiology Science and Production Center" of the Ministry of Health of the Russian Federation, 3rd Cherepkovskaya 15a, Moscow 121552

Keywords: dilated cardiomyopathy, stem cell, cell therapy, heart failure

DOI: 10.18087/rhfj.2017.3.2330

Dilated cardiomyopathy is currently defined by the presence of left ventricular (LV) or biventricular dilatation and systolic dysfunction in the absence of abnormal loading conditions (hypertension, valve disease) or coronary artery disease sufficient to cause global systolic impairment. Regardless of all of the advances in medical, pharmacological and surgical procedures, the fate of patients with dilated cardiomyopathy is linked to arrhythmic episodes, severe congestive heart failure and an increased risk of sudden cardiac death. In this review, we will summarize present data on the use of cell therapies in animal models of dilated cardiomyopathies and will discuss the few clinical trials that have been published so far involving patients affected by this disease.
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Safiullina A. A., Uskach T. M., Tereshchenko S. N., Zhirov I. V. Cell therapy for dilated cardiomyopathy: State-of-the-art. Russian Heart Failure Journal. 2017;18(3):225–232

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