2017


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2017/№2

Prevalence of rs10519210, rs1739843, and rs6787362 polymorphisms in patients with CHF of ischemic origin

Tishkova V. M., Prokopova L. V., Kostareva A. A., Sitnikova M. Yu.
Federal State Budgetary Institution "Federal Almazov North-West Medical Research Center" of the Ministry of Health of the Russian Federation, Akkuratova 2, St. Petersburg 197341

Keywords: heart failure, coronary heart disease, genetic cardiology, myocardial infarction, ejection fraction

DOI: 10.18087/rhfj.2017.2.2318

Background. Genome-wide association studies (GWAS) can identify patients with increased risk of HF after MI and facilitate development of preventive measures. Aim. To study prevalence of polymorphous alleles of HSPB7 (rs1739843), FRMD4B (rs6787362) genes and the 15q22 (rs10519210) locus associated with the HF syndrome as had been demonstrated by GWAS on a large sample of EU residents, in residents of the North-Western Federal District of the Russian Federation. Materials and methods. Men aged 30–65 who had had MI more than 3 months ago, were evaluated. The main group consisted of 260 patients with FC I–IV HF, LV EF (Simpson) <40%; the reference group included 96 donors. Results. The groups were comparable in the duration of AH (11.4 vs. 11.2 years) but different in the AH prevalence (68.5 and 83.3%; р<0.01). The main group contained more patients with complicated family history (34.23 and 22.88%; р<0.01), atrial fibrillation (AF) (31.2 and 14.4%; p<0.001), pulmonary artery thromboembolism (12.5 and 0.4%; р<0.001), and LV aneurism (20.6 and 0.9%; р<0.001). In the HF group with low EF, the QRS complex was wider (124.6±259.4 and 96.9±53.1ms; р<0.001) and pulmonary artery pressure was higher (46.3±48.7 and 30.2±24.8 mm Hg, р<0.001). Prevalence of the HSPB7В gene rs1736843 polymorphism was significantly different depending on the presence of HF and LV EF; in the main group, the CC genotype was found in 48.1% of patients and ТТ – in 10.4% of patients; in the reference group – in 80.9 and 7.3%; and in healthy subjects – in 80.2 and 4.2% of cases, respectively (p1–2, 1–3 <0.001). Prevalence of the FRMD4B gene also exceeded the significance threshold. In the main group, the AA genotype was observed in 83.5% of patients and GG in none of them; in the reference group – in 87.8 and 2.9%; and in healthy subjects – in 89.6 and 0%, respectively (p1–2, 3–2 <0.01). Prevalence of the USP3 gene did not differ between the study groups.
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Tishkova V. M., Prokopova L. V., Kostareva A. A., Sitnikova M. Yu. Prevalence of rs10519210, rs1739843, and rs6787362 polymorphisms in patients with CHF of ischemic origin. Russian Heart Failure Journal. 2017;18 (2):115–121

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