2017


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2017/№2

Markers of endothelial dysfunction in children with cardiovascular diseases

Tupikina A. A.1, Plotnikova I. V.1, Kovalev I. A.2, Svintsova L. I.1, Dzhaffarova O. Yu.1, Yanulevich O. S.1, Krivoshchekov E. V.1, Gusakova A. M.1
1 – Federal State Budgetary Science Institution "Tomsk National Research Medical Center of the Russian Academy of Science", "Cardiology Research Institute", Kievskaya 111a, Tomsk 634012
2 – Stand-alone Unit of the Federal State Budgetary Educational Institution of Higher Education, "N. I. Pirogov Russian National Research Medical University " of the Ministry of Health of the Russian Federation, "Academician Yu. E. Veltishchev Research Clinical Institute of Pediatrics", Taldomskaya 2, Moscow 125412

Keywords: endothelial dysfunction, heart failure, dilated cardiomyopathy, functional single heart ventricle, total cavopulmonary connection

DOI: 10.18087/rhfj.2017.2.2311

Background. At present time endothelial dysfunction (ED) is diagnosed in many patients with cardiovascular diseases. Aim. To evaluate concentrations of ED markers in children with dilated cardiomyopathy (DCMP) and functional single heart ventricle (FSHV) one year after total cavopulmonary connection (TCPC). Materials and methods. 27 patients with NYHA FC II HF were studied, including 16 children aged 3 to 16 years with FSHV following TCPC with extracardiac conduit one year after the surgery and 11 patients with DCMP aged 2 to 17 years. Mean age of patients was 8±4.5. Blood concentrations of ED biochemical markers, endothelin 1 (ET-1) and nitic oxide stable metabolites, were measured. Results. In patients with DCMP and FSHV, the median ET-1 concentration was higher than normal, 57.7 pg/ml (IQR: 7.2–172.8) and 51.2 pg/ml (IQR: 6.2–165.5), respectively. Median nitrite and nitrate concentrations were increased in both groups without significant differences between the groups (p=0.96 and р=0.98, respectively). Conclusion. Most patients with FSHV following TCPC and patients with DCMP had increased ET-1, which indicated the presence of ED irrespective of its etiology and pathogenesis. Increased levels of nitric oxide stable metabolites apparently evidenced the presence of chronic inflammation, probably of autoimmune origin.
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Tupikina A. A., Plotnikova I. V., Kovalev I. A., Svintsova L. I., Dzhaffarova O. Yu., Yanulevich O. S. et al. Markers of endothelial dysfunction in children with cardiovascular diseases. Russian Heart Failure Journal. 2017;18 (2):133–137

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