2017


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2017/№2

Genetic parallels of heart failure and chronic obstructive pulmonary disease

Hazova E. V., Bulashova O. V., Malkova M. I.
Federal State Budget Educational Institution of Higher Education, "Kazan State Medical University" of the Ministry of Health of the Russian Federation, Butlerova 49, Kazan 420012

Keywords: CHF, chronic obstructive pulmonary disease, A DR B2 gene polymorphism, comorbidity, cardio-respiratory association

DOI: 10.18087/rhfj.2017.2.2299

Comorbidity of cardiovascular and respiratory diseases is a serious problem due to unfavorable prognosis for this category of patients. Predisposition to the cardiorespiratory association is based on a pathological genotype that forms an unfavorable genetic background. This article focuses on genetic aspects of the clinical course of CHF and chronic obstructive pulmonary disease (COPD) in relation with β2-adrenoceptor (ADRB2) gene polymorphisms affecting the β2-adrenoceptor function. A high incidence of the ADRB2 gene Glu27Glu genotype (0.30) was observed in CHF patients from certain regions compared to groups without cardiovascular diseases (0.15) (р<0.05) whereas other studies did not report any relationship of this polymorphism with the risk or prognosis for CHF. Several studies have reported that allele variants of the ADRB2 gene at positions 16 and 27 may influence the lung function or predisposition to COPD. The genotype distribution differed in Caucasian and Asian populations for both positions 16 and 27 (р<0.05 except for the Arg16Gly genotype). A cohort study of patients with COPD of different severity discovered an association of the Arg16 allele and the Arg16/Gln27 haplotype with a reduced bronchodilatory response. Considering inconsistent results of studies presented in the analyzed literature, targeted search for genetic markers for development of the cardiorespiratory association should be performed with due account of population characteristics in order to individualize this approach in selecting a drug therapy to prolong quality life of patients.
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Hazova E. V., Bulashova O. V., Malkova M. I. Genetic parallels of heart failure and chronic obstructive pulmonary disease. Russian Heart Failure Journal. 2017;18 (2):138–143

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