2016

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2016/№6

Quality of life of patients with ischemic heart disease complicated with heart failure before and after transendocardial delivery of autologous bone-marrow-derived mononuclear cells

Kliver E.N., Chernyavsky A.M., Efremova O.S., Kliver E.E.
Federal State Budgetary Institution, "Academician E.N. Meshalkin Novosibirsk Research Institute of Circulatory Pathology " of the Ministry of Health of the Russian Federation, Rechkunovskaya 15, Novosibirsk 630055

Keywords: mononuclear fraction of autologous marrow cells, heart failure, ischaemic heart disease

DOI: 10.18087/rhfj.2016.6.2264

Background. Clinical use of endomyocardial injection of autologous mononuclear fraction of bone marrow cells (BMMNCs) in the treatment of heart failure attracted the attention of researchers. An important role in the assessment of these patients plays Quality of life (QOL) parameters. Aim. To evaluate quality of life of patients with pronounced ischemic myocardial dysfunction whose treatment included endomyocardial implantation of autologous bone marrow-derived mononuclear cell fraction (BMMNCF) using a NOGA navigation system in combination with modern drug therapy. Material and methods. Patients with LV EF≤35% (n=55) who underwent endomyocardial implantation of BMMNCF in combination with modern drug therapy. Quality of life was evaluated at baseline and at 6 months, 1 and 3 years of follow-up using the SF-36 questionnaire. Results. Both time-related changes and changes from baseline showed significant improvement in all indexes of the quality of life. PF (physical functioning) (scores 23.18±2.15 and 41.09±3.46, W=0.4; р=0.0000011); RE (emotional condition) (scores 36.00±1.29 and 48.53±3.65, W=0.65; р=0.0000076), and SF (social functioning) (scores 54.56±2.82 and 71.81±3.36, W=0.47; р=0.0000026) had the highest values of full functional dependency (W). Conclusion. Endomyocardial implantation of BMMNCF in combination with modern drug therapy improved the quality of life in patients with pronounced ischemic myocardial dysfunction in two years with slight decreases in RP (р=0.097) and GH (р=0.066) at the end of three-year follow-up.
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Kliver E.N., Chernyavsky A.M., Efremova O.S., Kliver E.E. Quality of life of patients with ischemic heart disease complicated with heart failure before and after transendocardial delivery of autologous bone-marrow-derived mononuclear cells. Russian Heart Failure Journal. 2016;17 (6):427–432

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