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Cardioprotection in myocardial ischemia and reperfusion injury

Astashkin E. I., Glezer M. G.
State Budgetary Educational Institution of Higher Professional Education “I. M. Sechenov First Moscow State Medical University” of the RF Ministry of Health Care, Trubetskaya 8, Bldg. 2, Moscow 119991

Keywords: ischemia, myocardial reperfusion, cardioprotective effect, preconditioning, postconditioning, necrosis, apoptosis, energy metabolism

DOI: 10.18087/rhfj.2016.3.2237

The review is dedicated to the 30th anniversary of discovering the effect of ischemic preconditioning, one of fundamental mechanisms for cell protection in ischemia and reperfusion. The authors addressed mechanisms of cardiomyocyte injury in ischemia and reperfusion, which can result in heart cell death and development of HF. Physiological and pharmacological approaches to cardioprotection are described.
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