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Role of a cardiologist in management of patients receiving antracyclines. Early detection and prevention of antracaycline-induced cardiomyopathy

Ovchinnikov A. G., Vitsenya M. V., Ageev F. T.
Federal State Budgetary Institution, “Russian Cardiology Science and Production Center” of the RF Ministry of Health Care, 3rd Cherepkovskaya 15a, Moscow 121552

Keywords: antracycline-induced cardiomyopathy, doxorubicin, left ventricular ejection fraction, troponin I, total systolic compression of the left ventricle, preventive measures

DOI: 10.18087/rhfj.2015.6.2159

The antitumor antibiotics, antracyclines, can cause severe LV systolic dysfunction characterized by extremely unfavorable prognosis. The review focuses on mechanisms of antracycline cardiotoxicity and the natural course of antracycline cardiomyopathy. RFs for antracycline cardiomyopathy are presented, among which the total antracycline dose and presence of CVD are the most important ones. The review discusses peculiarities of cardiologic management of patients and specifically stresses detection of the earliest and minor abnormalities of the LV function. Actions aimed at prevention and treatment of antracycline-induced cardiomyopathy are listed.
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Ovchinnikov A. G., Vitsenya M. V., Ageev F. T. Role of a cardiologist in management of patients receiving antracyclines. Early detection and prevention of antracaycline-induced cardiomyopathy. Russian Heart Failure Journal. 2015;16 (6):396–404

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