2015


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2015/№5

Prognostically significant clinical phenotypes of patients with circulatory decompensation in the russian federation

Arutyunov A. G., Dragunov D. O., Arutyunov G. P., Rylova A. K., Sokolova A. V., Rylova N. V.
State Budgetary Educational Institution of Higher Professional Education, “N. I. Pirogov Russian National Research Medical University” of the RF Ministry of Health Care, Ostrovityanova 1, Moscow 117997

Keywords: patient phenotype, circulatory decompensation, comorbidity, pneumonia, chronic kidney disease, anemia, chronic infection, mortality

DOI: 10.18087 / rhfj.2015.5.2135

Background. In routine medical practice, clinical phenotyping remains one of the most promising methods of prognosis for patients admitted for circulatory decompensation. Aim. To determine clinical phenotypes with significant negative predictive influence on risk of a fatal outcome in patients with acute circulatory decompensation based on analysis of data from two registers (the “Pavlov Hospital Register” at the Moscow Municipal Clinical Hospital #4 and the “ORACLE-RF” Register formed at 40 centers in 20 cities). Materials and methods. The analysis included 3 451 patients with circulatory decompensation. Results. Based on analysis of continuous and binary predictors for a fatal outcome, 36 clinical groups were formed. Using the method of sequential analysis, clusters including the largest number of patients were formed from these groups. Five clinical phenotype clusters were formed. Conclusion. The leading role in prediction of adverse outcomes was shown for extracardiac predictors in patients with circulatory decompensation, pneumonia, chronic infection, anemia, and tachysystole.
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Arutyunov A. G., Dragunov D. O., Arutyunov G. P., Rylova A. K., Sokolova A. V., Rylova N. V. Prognostically significant clinical phenotypes of patients with circulatory decompensation in the Russian Federation. Russian Heart Failure Journal. 2015;16 (5):270–278

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