Russian Heart Failure Journal 2015year Effect of anxiety-depressive disorders on exercise tolerance of patients with chronic heart


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2015/№3

Effect of anxiety-depressive disorders on exercise tolerance of patients with chronic heart

Vatutin N. T., Khristichenko M. A.
“M. Gorky Donetsk National Medical University” of the Ukraine Ministry of Health Care, Prospekt Iljicha 6, Donetsk, Ukraine

Keywords: CHF, exercise tolerance, anxiety-depressive disorders

DOI: 10.18087/rhfj.2015.3.2073

Background. Despite considerable progress in treatment of CHF its prognosis remains unfavorable. Combination of affective disorders and CHF can aggravate prognosis and significantly impair not only the course of somatic disease but also quality of life in such patients. Aim. To evaluate the effect of presence and severity of anxiety-depressive disorders (ADD) on exercise tolerance (ET) of CHF patients. Materials and methods. 142 patients (85 males and 57 females, mean age 66.4±10.5) with NYHA FC II–IV CHF were evaluated. The Hospital Anxiety and Depression Scale (HADS) was used for detection and assessment of anxiety and depression severity. The 6‑min walk test (6WT) was performed for all patients to evaluate ET. Results. Based on results of the scales, patients were divided into two groups: group 1 consisted of 111 (78.1 %) patients with ADD; group 2 included 31 (21.9 %) patients without ADD. In group1, the 6WT result was 224.1±11.1 m; in group 2–253.9±17.5 m (р<0.05). Furthermore, the lowest ET values (151.7±9.2 m) were observed in a subgroup of patients with a combination of anxiety and depression. ADD severity clearly correlated with the walk distance (correlation coefficient, –0.79). Conclusion. The presence of ADD is associated with reduced ET according to 6WT data. A combination of anxiety and depressive disorders results in the most significant decrease in ET compared to an isolated affective disorder.
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Vatutin N. T., Khristichenko M. A. Effect of anxiety-depressive disorders on exercise tolerance of patients with chronic heartю Russian Heart Failure Journal. 2015;16 (3):167–170

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