Russian Heart Failure Journal 2015year Diagnostic significance of biological markers in chronic heart failure with preserved left ventricular ejection fraction


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2015/№1

Diagnostic significance of biological markers in chronic heart failure with preserved left ventricular ejection fraction

Bazaeva E. V., Myasnikov R. P., Metelskaya V. A., Boytsov S. A.
Federal State Budgetary Institution, "National Research Center for Preventive Medicine" of the RF Ministry of Health Care, Petroverigsky Per. 10, Bld 3, Moscow 101990

Keywords: diagnostics, preserved ejection fraction, CHF

DOI: 10.18087/rhfj.2015.1.2038

In the recent 15 years, the classic approach to diagnosing CHF provides for division into systolic and diastolic forms. Diastolic CHF is associated with signs of impaired relaxation and filling, loss of elasticity, and increased rigidity of LV. Such cases imply HF with preserved LV EF (HF-PLVEF). This group includes patients with normal (>50%) or practically unchanged (40–50%) LV EF; however the life prognosis for such patients has been shown to be worse that for patients with LV EF >50%. A reason for including patients with LV EF 40–50% or higher into the group with diastolic CHF is that their prognosis is considerably better than for patients with systolic CHF. Mechanisms of HF-PLVEF development are heterogeneous and understudied. HF-PLVEF has been suggested to be induced not only by impaired LV compliance but also by complex biochemical processes affecting cardiomyocytes and myocardial interstitium. Clinical manifestations of CHF are not sufficiently specific, and EchoCG not always detects significant disorders of the LV diastolic function. Therefore, in suspected HF-PLVEF, measurement of blood biomarkers can be used as an alternative diagnostic approach, since their concentrations increase in organic damage of the heart. This review discusses the place and role of biological markers in diagnostics of HF-PLVEF.
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Bazaeva E. V., Myasnikov R . P., Metelskaya V. A. et al. Diagnostic significance of biological markers in chronic heart failure with preserved left ventricular ejection fraction. Russian Heart Failure Journal. 2015;16 (1):43–51

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