Russian Heart Failure Journal 2015year Treatment of CHF patients based on monitoring of natriuretic peptide concentrations. Patient characteristics and study design


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2015/№1

Treatment of CHF patients based on monitoring of natriuretic peptide concentrations. Patient characteristics and study design

Koshkina D. E., Skvortsov A. A., Protasov V. N., Narusov O. Yu., Masenko V. P., Tereshchenko S. N.
Federal State Budgetary Institution, "Russian Cardiology Scientific and Production Center" of the RF Ministry of Health Care, 3rd Cherepkovskaya 15a, Moscow 121552

Keywords: NT-proBNP, treatment, CHF

DOI: 10.18087/rhfj.2015.1.2027

Background. Decreased concentration of NT-proBNP is associated with improved prognosis for patients with HF. However it is presently unclear whether intensive drug therapy for HF aimed at minimizing concentrations of natriuretic peptides (NUPs) has any advantage over a standard therapy. Aim. To evaluate expediency of a therapeutic tactics based on monitoring of NT-proBNP concentrations vs. a standard therapy in patients with high-risk CHF. Materials and methods. This single-center prospective study included 105 patients aged 18 to 75 with FC III–IV decompensated HF and LV EF <40 %. At discharge, high-risk patients were randomized to the standard treatment group and the group of treatment based on monitoring of NT-proBNP concentration at a ratio of 1:1. The study goal of NT-proBNP concentration was established at the level of <1000 pg / ml. The primary endpoint was a composite endpoint of cardiovascular mortality, decompensated HF, and rehospitalization for decompensated HF. Secondary endpoints were surrogate; efficacy and safety of the treatment were evaluated based on these endpoints. Results. This article presents the study design and detailed patient characteristics. The results will be published in detail in 2015. Conclusion. Results of this study may underlie development of a new approach to the treatment of high-risk HF patients who require intensified control and individualized tactics of the management to optimize the treatment and to improve the clinical condition, quality of life, and prognosis for these patients.
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Koshkina D. E., Skvortsov A. A., Protasov V. N. et al. Treatment of CHF patients based on monitoring of natriuretic peptide concentrations. Patient characteristics and study design. Russian Heart Failure Journal. 2015;16 (1):3–10

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