2015


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2015/№2

Do β-adrenoblockers improve prediction for CHF patients? – A clinical and genetic study in the Tatarstan Republic region

Khazova E. V.1, Bulashova O. V.1, Gazizyanova V. M.1, Kravtsova O. A.2, Malkova M. I.1
1 – State Budgetary Educational Institution, "Kazan State Medical University" of the RF Ministry of Health Care, Butlerova 49, Kazan 420012
2 – Federal State Autonomous Educational Institution, "Kazan Federal University" of the RF Ministry of Health Care, Kremlevskaya 18, Kazan 420008

Keywords: beta-adrenergic blocker agents, treatment, prognosis, Republic of Tatarstan, CHF

DOI: 10.18087/rhfj.2015.2.2048

Background. At present, more than 20 placebo-controlled studies have demonstrated improved prediction and decreased mortality in patients with FC II–IV CHF receiving a drug therapy, which included β-blockers (BB). Nevertheless markers for unfavorable outcome in BB-treated patients have been continuously searched for. Aim. To analyze outcomes in CHF patients in the aspect of Arg16Gly and Gln27Glu polymorphisms in the ADRB2 gene and to evaluate the BB efficacy. Materials and methods. The study included 144 CHF patients of the hospital registry in the Tatarstan Republic region. Variants of ADRB2 Arg16Gly and Gln27Glu genes were determined. Information about cardiovascular events during one year of the study was considered. Endpoints included all-cause death, non-fatal MI and brain stroke (BS), hospitalization for decompensated CHF, and newly diagnosed diabetes mellitus (DM). Results. Irrespective of the variant of ADRB2 gene polymorphism, inclusion of BB into the drug complex improved the prediction by decreasing the number of fatal outcomes and non-fatal MI. At the same time, the BB treatment was associated with more cases of newly diagnosed DM with Arg16 / Arg genotype of the ADRB2 gene. Genotype Gly 16 Gly of the ADRB2 gene was found twice as frequently in patients receiving BB.
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Khazova E. V., Bulashova O. V., Gazizyanova V. M. et al. Do β-adrenoblockers improve prediction for CHF patients? – A clinical and genetic study in the Tatarstan Republic region. Russian Heart Failure Journal. 2015;16 (2):106–111

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