2015


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2015/№1

Prognostic significance of left atrial volume in patients with hypertrophic cardiomyopathy

Komissarova S. M.1, Ustinova I. B.1, Sevruk I. V.1, Mrochek A. G.1, Krasko O. V.2
1 – State Institution, Republican Science and Practice Center "Cardiology", R. Luxemburg 110, Minsk 220036, Belarus
 2 – State Science Institution, "United Institute of Informatics Problems of the Belarus National Academy of Sciences", Surganova 6, Minsk 220012, Belarus

Keywords: HCMP, diagnostics, prognosis, echocardiography

DOI: 10.18087/rhfj.2015.1.2007

Background. Prediction of unfavorable outcome for patients with hypertrophic cardiomyopathy (HCMP) is still a complicated and not fully solved challenge. Aim. To determine the predictive value of EchoCG left atrial volume (LAV) in HCMP patients with preserved LV systolic function. Materials and methods. Clinico-demographic and instrumental indexes were analyzed for 154 patients with HCMP (102 males and 52 females, median age 45) who were observed at the Republican Science and Practice Center “Cardiology” from October, 2001 through October, 2013. Median observation period was 3.2 years (from 0.7 to 12.5 years). Patients were divided into two groups, with and without unfavorable outcomes. Results. For the observation period, we recorded 6 fatal outcomes due to sudden cardiac death (SCD); a cardioverter (CV) was implanted into 4 SCD patients after successful resuscitation; and two patients had stroke. The ratio of LAV to body surface area (LAV / BSA) was a statistically significant factor associated with an unfavorable outcome in the study cohort. Conclusion. The LAV / BSA value >41 ml / m2 identifies patients with unfavorable course of disease with sensitivity of 92 % and specificity of 75 %. For the observation period, survival was 98.5 % (95.7–100 %) for patients with LAV / BSA ≤41 ml / m2 and 55.8 % (36.3–85.8 %) for patients with LAV / BSA >41 ml / m2.
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Komissarova S. M., Ustinova I. B., Sevruk I. V. et al. Prognostic significance of left atrial volume in patients with hypertrophic cardiomyopathy. Russian Heart Failure Journal. 2015;16 (1):31–36

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