2014


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2014/№6

Factors associated with progression of chronic heart failure in patients with hypertrophic cardiomyopathy

Komissarova S. M.1, Ustinova I. B.1, Sevruk I. V.1, Krasko O. V.2, Mrochek A. G.1
1 – State Institution Republican Science and Practice Center “Cardiology”, R. Luxemburg 110, Minsk, Belarus
2 – State Scientific Institution, “United Institute of Informatics at the National Academy of Sciences of Belarus”, Surganova 6, Minsk, Belarus

Keywords: hypertrophic cardiomyopathy, heart failure, risk factors


DOI: 10.18087/rhfj.2014.6.2009

Background. Prognosis for patients with hypertrophic cardiomyopathy (HCMP) and symptoms of HF progression remains a complicated and not completely solved issue. Factors for identification of HCMP patients at high risk of adverse events have been proposed. Aim. To evaluate effects of factors associated with CHF progression at early stages of CHF in patients with HCMP. Materials and methods. Clinico-demographic and instrumental data were analyzed for 214 patients with HCMP (139 males and 75 females; median age, 47) admitted to the Republican Science and Practice Center “Cardiology” between 2007 and 2013. Results. Mono- and multifactorial analyses with logit-regression showed that in the study group, risk factors (RFs) for adverse events induced by CHF progression included age ≥50; LV outflow tract pressure gradient (LVOT PG) >21 mm Hg; LV EF ≤60 %; and plasma NТ-proBNP >30 fmol / ml. In addition to known factors facilitating CHF progression in HCMP patients (age, LVOT PG, LV EF), NT-proBNP level was the strongest predictor for development of adverse events in HCMP. Conclusion. In addition to objective clinical manifestations of CHF and known factors facilitating CHF progression, we recommend using plasma levels of NТ-proBNP to identify patients at high risk, for administration of more intensive monitoring and more effective therapy.
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Komissarova S. M., Ustinova I. B., Sevruk I. V. et al. Factors associated with progression of chronic heart failure in patients with hypertrophic cardiomyopathy. Russian Heart Failure Journal. 2014;15 (6):347–354

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