2014


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2014/№4

Effect of coenzyme Q₁₀ used as a part of standard therapy on plasma levels of brain natriuretic peptide in patients with chronic heart failure

Tokareva O. G., Kharitonova E. V., Mareev V. Yu., Kalenikova E. I., Medvedev O. S.
Federal State Budgetary Educational Institution of Higher Professional Education “M. V. Lomonosov Moscow State University”, Leninskie Gory 1, GSP-1, Moscow 119991

Keywords: coenzyme Q, natriuretic peptide, CHF


DOI: 10.18087/rhfj.2014.4.2002

Background. Along with a standard therapy for CHF, additional myocardial cytoprotection is highly significant as it restricts increased production of reactive oxygen species and enhances effectiveness of energy-dependent processes. One of cardioprotectors recommended for the use in CHF is coenzyme Q10 (CoQ10). Aim. To study effects of ubidecarenone (coenzyme Q10, Kudesan®) on plasma level of brain natriuretic peptide (BNP) in patients with FC II-III CHF. Materials and methods. The study included 78 patients aged 40 to 70 years with FC I-III CHF. Participants of the study received CoQ10 (90 mg / day) or placebo as a supplement to their standard therapy for 24 weeks. Before the treatment and in 6 months, LV EF was measured, 6-min walk test was performed, and blood plasma was collected for measuring BNP and CoQ10 in all patients. Results. Long-term CoQ10 treatment prevented progression of CHF associated with impaired myocardial contractility and normal baseline BNP levels (below 100 pg / ml). In patients with increased baseline BNP levels (above 100 pg/ml) addition of the CoQ10 drug to the standard therapy significantly reduced BNP levels, increased LV EF, and enhanced exercise tolerance.
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Tokareva O. G., Kharitonova E. V., Mareev V. Yu. et al. Effect of coenzyme Q₁₀ used as a part of standard therapy on plasma levels of brain natriuretic peptide in patients with chronic heart failure. Russian Heart Failure Journal. 2014;85 (4):232–237

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