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Anemia in chronic heart failure: Role of hepcidin as a universal regulator of iron metabolism

Solomakhina N. I., Nakhodnova E. S., Ershov V. I.
Federal State Budgetary Educational Institution of Higher Education "I. M. Sechenov First Moscow State Medical University” of the RF Ministry of Health Care, Trubetskaya 8, Bldg. 2, Moscow 119991

Keywords: anemia, hepcidin, treatment, CHF

DOI: 10.18087/rhfj.2014.4.1931

At present, anemias called “anemia of chronic disease” (ACD) are isolated from the group of iron-deficiency anemias. In ACD, no specific “classic” cause can be identified to classify the anemia as a known clinical and pathogenetic type. Furthermore, ACDs are very heterogeneous in nature and are distinguished by their variable origin and simultaneous contribution of many factors regulating erythropoiesis. This type of anemia is particularly important in CHF which is associated with ACD in many patients according to reports from large epidemiological studies of recent decades. The presence of anemia, which aggravates hypoxia in this patient category, requires both profound studies of its pathogenesis and development of efficient methods for its correction. At present time, researchers are focused on several, most important stages of ACD development, particularly the recently discovered hormone-like protein, hepcidin.
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Solomakhina N. I., Nakhodnova E. S., Ershov V. I. Anemia in chronic heart failure: Role of hepcidin as a universal regulator of iron metabolism. Russian Heart Failure Journal. 2014;85 (4):254–260

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