2014


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2014/№2

Mild kidney dysfunction in patients with heart failure: preclinical signs and their predictive significance

Kuzmin O. B., Belyanin V. V., Zhezha V. V.

Keywords: kidney dysfunction, prognosis, glomerular filtration rate, CHF

DOI: 10.18087/rhfj.2014.2.1905

The review discusses results of clinical studies focused on the relationship of slightly reduced GFR (60–74 ml / min / 1.73 m2), microalbuminuria and high urinary levels of biomarkers for renal tubular injury with overall mortality and cardiovascular outcomes in CHF patients with slight kidney dysfunction.
  1. Hillege HL, Nitsch D, Pfeffer MA et al. Renal function as a predictor of outcome in a broad spectrum of patients with heart failure. Circulation. 2006;113 (5):671–678.
  2. Khan NA, Ma I, Thompson CR et al. Kidney function and morta­lity among patients with left ventricular systolic dysfunction. J Am Soc Nephrol. 2006;17 (1):244–253.
  3. Ahmed A, Rich MW, Sanders PW et al. Chronic kidney disease associated with mortality in diastolic versus systolic heart failure. Am J Cardiol. 2007;99 (3):393–398.
  4. Арутюнов Г. П. Патофизиологические процессы в почках у больных хронической сердечной недостаточностью. Журнал Сердечная Недостаточность. 2008;9 (5):234–250.
  5. Кузьмин О. Б. Механизмы развития и прогрессирования нефропатии у больных сердечной недостаточностью с хроническим кардиоренальным синдромом. Нефрология. 2011;15 (2):20–29.
  6. ADQI 7: the clinical management of the cardio-renal syndromes: work group statements from the 7th ADQI consensus conference. Nephrol Dial Transplant. 2010;25 (7):2077–2089.
  7. Mann JF, Gerstein HC, Pogue J et al. Renal insufficiency as a predictor of cardiovascular outcomes and the impact of ramipril: the HOPE randomized trial. Ann Intern Med. 2001;134 (8):629–636.
  8. Ruilope LM, Salvetti A, Jamerson K et al. Renal function and intensive lowering of blood pressure in hypertensive participants of the hypertension optimal treatment (HOT) study. J Am Soc Nephrol. 2001;12 (2):218–225.
  9. Mancia G, De Backer G, Dominiczak A et al. 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2007;25 (6):1105–1187.
  10. Моисеев В. С., Мухин Н. А., Кобалава Ж. Д. и др. Практические рекомендации. Функциональное состояние почек и прогнозирование сердечно-сосудистого риска. Клиническая фармакология и терапия. 2009;18 (4):75–79.
  11. Vanholder R, Massy Z, Argiles A et al. Chronic kidney disease as cause of cardiovascular morbidity and mortality. Nephrol Dial Transplant. 2005;20 (6):1048–1056.
  12. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16 (1):31–41.
  13. Levey AS, Greene T, Kusek JW, Beck GJ. A simplified equation to predict glomerular filtration rate from serum creatinine. J Am Soc Nephrol. 2000;11 (Suppl.): 155A.
  14. Levey AS, Stevens LA, Schmid CH et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150 (9):604–612.
  15. McAlister FA, Ezekowitz J, Tarantini L et al. Renal dysfunction in patients with heart failure preserved versus reduced ejection fraction: impact of the new Chronic Kidney Disease Epidemiology Collaboration Group formula. Circ Heart Fail. 2012;5 (3):309–314.
  16. Inker LA, Shaffi K, Levey AS. Estimation glomerular filtration rate using the chronic kidney disease-epidemiology collaboration crea­tinine equation: better risk predictions. Circ Heart Fail. 2012;5 (3):303–306.
  17. Shantsila E, Wrigley BJ, Blann AD et al. A contemporary view on endothelial dysfunction in heart failure. Eur J Heart Fail. 2012;14 (8):873–881.
  18. Futracul N, Sridama V, Futracul P. Microalbuminuria – a biomarker of renal microvascular disease. Ren Fail. 2009;31 (2):140–143.
  19. Кузьмин О. Б., Бучнева Н. В., Пугаева М. О. Почечные гемодинамические механизмы формирования гипертонической нефропатии. Нефрология. 2009;13 (4):28–36.
  20. Clinical Practice Guidelines. Current issue in the management of chronic kidney disease. Kidney Int. 2010;78 (Suppl): S1‑S45. Hillege HL, Janssen WM, Bak AA et al. Microalbuminuria is common, also in a nondiabetic, nonhypertensive population, and an independent indicator of cardiovascular risk factors and cardiovascular morbidity. J Intern Med. 2001;249 (6):519–526.
  21. Weir R. Microalbuminuria and cardiovascular disease. CJASN. 2007;2 (3):581–590.
  22. Smith GL, Lichtman JH, Bracken MB et al. Renal impairment and outcomes in heart failure: systematic review and meta-analysis. J Am Coll Cardiol. 2006;47 (10):1987–1996.
  23. Шутов А. М., Курзина Е. В., Серов В. А., Ивашкина Т. К. Дис­функция почек и митральная регургитация у больных с хронической сердечной недостаточностью. Терапевтический архив. 2008;80 (9): 31–35.
  24. Ovedeji AT, Balogun MD, Akintomide AA et al. The significance of mild renal dysfunction in chronic heart failure. West Afr J Med. 2011;30 (6):442–446.
  25. Stanojevic D, Apostolovic S, Jancovic R et al. Prevalence of renal dysfunction and its influence on functional capacity in elderly patients with stable chronic heart failure. Voinosanit Preql. 2012;69 (10):840–845.
  26. Шутов А. М., Серов В. А., Курзина Е. В. Хроническая болезнь почек и фибрилляция предсердий у пациентов с хронической сердечной недостаточностью. Терапевтический архив. 2009;81 (12):23–26.
  27. van de Wal RM, Asselbergs FW, Plokker HW et al. High prevalence of microalbuminuria in chronic heart failure patients. J Card Fail. 2005;11 (8):602–606.
  28. Orea-Tejeda A, Colin-Ramirez E, Hernandez-Gilsoue T et al. Microalbuminuria in systolic and diastolic chronic heart failure patients. Cardiol J. 2008;15 (2):143–149.
  29. Jackson CE, Solomon SD, Gerstein HC et al. Albuminuria in chro­nic heart failure: prevalence and prognostic importance. Lancet. 2009;374 (9689):543–550.
  30. Masson S, Latini R, Milani V et al. Prevalence and prognostic value of elevated urinary albumin excretion in patients with chronic heart failure: data from GISSI-Heart Failure trial. Circ Heart Fail. 2010;3 (1):65–72.
  31. Waheed S, Matsushita K, Sanq Y et al. Combined association of albuminuria and cystatin C-based estimation of GRF with mortality, coronary heart disease and heart failure outcomes: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Kidney Dis. 2012;60 (2):207–216.
  32. Kang HK, Kim DK, Lee BH et al. Urinary N-acetyl-beta-D-glucosaminidase and malondialdehyde as a markers of renal da­mage in burned patients. J Rorean Med Sci. 2001;16 (5):598–602.
  33. Liangos O, Perianayagan MC, Vaidya VS et al. Urinary N-acetyl-beta- (D) – glucosaminidase activity and kidney injury molecule-1 level are associated with adheres outcomes in acute renal failure. J Am Soc Nephrol. 2007;18 (3):904–912.
  34. van Timmeren MM, van den Heuvel MC, Bailly V et al. Tubular kidney injury molecule-1 (KIM-1) in human renal disease. J Pathol. 2007;212 (2):209–217.
  35. Lim AI, Tanq SC, Lai KN, Leung JC. Kidney injury molecule-1: more than just an injury marker of the epithelial cells. J Cell Physiol. 2013;228 (5):917–924.
  36. Damman K, van Veldhuisen DJ, Navis G et al. Tubular damage in chronic systolic heart failure is associated with reduced survival independent of glomerular filtration rate. Heart. 2010;96 (16):1297–1302.
  37. Jungbauer CG, Birner C, Jung B et al. Kidney injury molecule-1 and N-acetyl-β-D-glucosaminidase in chronic heart failure: possible biomarkers of cardiorenal syndrome. Eur J Heart Fail. 2011;13 (10):1104–1110.
  38. Damman K, Masson S, Hillege HL et al. Clinical outcome of renal tubular damage in chronic heart failure. Eur Heart J. 2011;32 (21):2705–2712.
Kuzmin O.B., Belyanin V.V., Zhezha V.V. Mild kidney dysfunction in patients with heart failure: preclinical signs and their predictive significance. Russian Heart Failure Journal. 2014;83 (2):126–131

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