Effect of acute kidney injury on prognosis in patients with acute decompensation of chronic heart failure
Makeeva E. R., Menzorov M. V., Shutov A. M., Serov V. A., Saenko Yu. V., Strakhov A. A.
Keywords: circulatory decompensation, acute kidney injury, prognosis, CHF
Background. Rate and severity of acute kidney injury (AKI) in patients with acute decompensated HF (ADHF) are understudied. Aim. To evaluate rate and severity of AKI in patients with ADHF and to specify the relationship of AKI with mortality. Materials and methods. The study included 104 patients with ADHF, 58 (56 %) males and 46 (44 %) females, mean age 65.3±10.7 years. In most of the patients (82, 79 %), HF was induced by IHD. ADHF was diagnosed according to Russian Society of Cardiology Guidelines. AKI was diagnosed and classified according to KDIGO Guidelines (2012). Results. AKI was diagnosed by creatinine level in 76 (73 %) patients. Stage 1 AKI was diagnosed in 61 (59 %) patients; stage 2 – in 13 (12 %) patients, stage 3 – in 2 (2 %) patients. Five (5 %) patients died during the hospitalization period. All dead patients had AKI. The probability of hospital mortality was higher for patients with stage 2–3 AKI than for other patients (OR, 11.2; 95 % CI 1.6–76.3). Conclusion. More than a half of ADHF patients have AKI. Most of the patients (59 %) have stage 1 AKI. Hospital mortality is higher for patients with stage 2–3 AKI than for patients without AKI.
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Makeeva E. R., Menzorov M. V., Shutov A. M. et al. Effect of acute kidney injury on prognosis in patients with acute decompensation of chronic heart failure. Russian Heart Failure Journal. 2014;15(1):32–38.