A case of recurrent neutropenia tentatively induced by propafenon, spironolactone, and valsartan in a female patient with atrial fibrillation, arterial hypertension and CHF
Shuev G. N., Payushchik S. A., Sychev D. A., Otdelenov V. A., Kleymenova E. B.
Keywords: valsartan, drug-induced neutropenia, propafenon, spironolactone
Drug-induced neutropenia is a severe condition resulting from a dangerous, adverse side reaction, which may cause various complications including death. A case is described of recurrent drug-induced neutropenia in a 55 year old woman with paroxysmal atrial fibrillation, 3d degree AH and CHF. The first neutropenia episode was associated with the onset of propafenon treatment; the second episode developed, when spironolactone was added to the therapy; and in the third episode, leucopenia developed after addition of valsartan. After withdrawal from the therapy, the leukocyte count returned to normal. Recurrent neutropenia causes considerable difficulties in the choice of drug therapy. It implies the necessity for frequent monitoring of blood count, to avoid administration of the drugs, which have been shown to induce neutropenia, and to provide at the same time adequate treatment of the underlying disease.
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Shuev G.N., Payushchik S.A., Sychev D.A. et al. A case of recurrent neutropenia tentatively induced by propafenon, spironolactone, and valsartan in a female patient with atrial fibrillation, arterial hypertension and CHF. Russian Heart Failure Journal. 2013;14 (5):309-312