2012


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2012/№6

Genetic predictors of chronic heart failure development in hypertensive patients in the Republic of Mordovia

Arutiunov G. P., Goncharova L. N., Postnov A. Yu.

Keywords: hyperpiesis, ethnic origin, angiotensin-converting enzyme gene polymorphism, АТ2R1 polymorphism, beta adrenoreceptors gene polymorphism, Republic of Mordovia, CHF

DOI: 10.18087 / rhfj.2012.6.1767

Relevance. In Russian Federation, hypertension was diagnosed at one third of adult population and is one of the major predictors of CHF development. Objective. Study associations of the main hemodynamic characteristics with polymorphism of RAC and beta adrenoretceptor genes and gene-gene relations to reveal signs of CHF in hypertensive patients of Republic of Mordovia. Materials and methods. 291 patient with primary hypertension of Russian and Mordovian (mordva-moksha and mordva-erzia) origin were examined according to the standard technique. EchoCG study, analysis of polymorphic markers by the method of polymerase chain reaction with use of the corresponding primers were performed. Results. It was revealed that hypertensive patients of the Mordovian origin, who are carriers of “adverse” genotypes of ACE and АТ2R1 genes, are characterized by significant increase of ESD, EDD, ММLV and low EF, and younger age of patients at combination of “adverse” genotypes of RAC genes. Conclusion. Study of RAC gene polymorphism and their combination in hypertensive patients of the Mordovian origin in the Republic of Mordovia will allow revealing predisposition to earlier development of CHF in due time.
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Arutiunov G. P., Goncharova L. N., Postnov A. Yu. Genetic predictors of chronic heart failure development in hypertensive patients in the Republic of Mordovia. Russian Heart Failure Journal. 2012;13(6):355-364

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