2012


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2012/№2

Interrelation of vascular stiffness indices and central blood pressure with lesions of target organs

Ivanenko V. V., Rotar O. P., Konradi A. O.
Federal State Budgetary Institution, “North-West Federal Medical Research Center” of the RF Ministry of Health Care, Akkuratova 2, St.-Petersburg 197341

Keywords: arterial hypertension, vascular stiffness, target organs, risk factors, central pressure

DOI: 10.18087 / rhfj.2012.2.1643

Relevance. Data have been collected until now, which allow considering state of great vessels walls, especially indices of vascular stiffness as a risk factor of cardiovascular complications and lesions of target organs. Objective. Reveal relation of vascular stiffness indices and central BP with lesions of other target organs and evaluate dynamics of target organs state against the reduction of vascular stiffness and central blood pressure due to antihypertensive therapy. Materials and methods. The study included relatively healthy subjects with BP above 140 / 90 mm Hg and / or had one of the risk factors (overweight, dislipidemy, increased plasma glucose). The study included measurement of anthropometric parameters, BP, heart rate, plasma glucose levels and fats. EchoCG examinations were carried out; ankle-brachial index was calculated, carotid intimal medial thickness, central pressure, pulse wave velocity. All subjects (84 persons) received antihypertensive therapy during 12 months. Results. In AH patients vessel wall lesions were closely associated with lesions of other target organs, which can be used for risk stratification and secondary preventive measures. Against long-term antihypertensive therapy, reduction of vascular stiffness correlated with better state of other target organs.
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Ivanenko V. V., Rotar O. P., Konradi A. O. Interrelation of vascular stiffness indices and central blood pressure with lesions of target organs. Russian Heart Failure Journal. 2012;13(2):101-104

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