Russian Heart Failure Journal 2012year Chronic heart failure in patients with venous thromboembolic complications. Influence on D-dimer levels, efficacy and safety of long-term anticoagulant therapy


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2012/№1

Chronic heart failure in patients with venous thromboembolic complications. Influence on D-dimer levels, efficacy and safety of long-term anticoagulant therapy

Vorobieva N. M.1, Panchenko E. P.1, Dobrovolskiy A. B.1, Titaeva E. V.1, Ermolina O. V.1, Balakhonova T. V.1, Kirienko A. I.2
1 – Federal State Budgetary Institution, “Russian Cardiology Research and Production Complex” of the RF Ministry of Health Care, 3rd Cherepkovskaya 15a, Moscow 121552
2 – State Budgetary Educational Institution of Higher Professional Education, “N.I. Pirogov Russian National Research Medical University” of the RF Ministry of Health Care, Ostrovityanova 1, Moscow 117997

Keywords: anticoagulants, venous thromboembolic events, d-dimer, CHF

DOI: 10.18087 / rhfj.2012.1.1642

Relevance. Chronic HF is a procoagulant condition and independent uncorrectable risk factor of venous thromboembolic events (VTE). Objective. Study of CHF influence on D-dimer levels, efficacy and safety of long-term anticoagulant therapy in patients who had VTE. Materials and methods. The study included 97 patients with VTE (67 male, 30 female) at the age of 18–76 years, who had suffered the first or repeated deep vein thrombosis (DVT) and / or pulmonary embolism event, who had no contraindications for anticoagulant therapy. All patients received unfractioned or low molecular weight heparin with subsequent transfer to warfarin with control of international normalized ratio (targeted INR values 2.0–3.0). US angio scan of extremities was performed and D-dimer levels were measured initially, in 1, 3, 6, 12, and 18 months. Results. CHF did not increase risk of hemorrhagic complications, but was not associated with increased risk of DVT recurrence (relative risk 3.8) and increased levels of D-dimer (relative risk 3.3) during anticoagulant therapy in comparison with VTE patients without CHF.
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Vorobieva N. M., Panchenko E. P., Dobrovolskiy A. B. et al. Chronic heart failure in patients with venous thromboembolic complications. Influence on D-dimer levels, efficacy and safety of long-term anticoagulant therapy. Russian Heart Failure Journal. 2012;13(1):53-59

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