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High blood serotonin levels – marker of CHF or depression?

Kirillova V. V., Prosviryakov E. Yu.

Keywords: 5-hydroxyindoleacetic acid, depression, blood, noradrenaline, serotonin, CHF

DOI: 10.18087/rhfj.2012.1.1647

Relevance. Role of serotonin in the pathogenesis of depression and CHF has not been completely studied to date. Objective. Estimate blood concentrations of serotonin, 5‑hydroxyindoleacetic acid (5‑HIAA), 5 НТ / 5‑HIAA, noradrenaline in CHF patients depending on occurrence of depression. Materials and methods. Blood concentrations of serotonin, 5‑HIAA, noradrenaline were estimated by HPLC electrochemical detection in patients with CHF FCI–III (New-York classification), with and without depression. Control group comprised male patients of the same age as in the study groups, who had no CVDs in the past history and by echoCG data. Results. CHF patients had higher blood concentrations of serotonin, 5‑HIAA in comparison with the control group (1540.4±240.98 nmol / l and 100.3±6.34 nmol / l versus control 375.19±158.08 nmol / l; 25.77±3.18 nmol / l), (p<0,01). Noradrenaline concentration in CHF patients did not differ from the control (2.74±0.81 nmol / l versus control 3.97±0.31 nmol / l). Serotonin, 5‑HIAA, noradrenaline concentrations in patients did not differ depending on occurrence of depression. Conclusion. Thus, increased serotonin concentration, its metabolism, missing noradrenaline concentration changes in CHF patients with and without depression.
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Kirillova V. V., Prosviryakov E. Yu. High blood serotonin levels – marker of CHF or depression? Russian Heart Failure Journal. 2012;13(1):36-39

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