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Systolic and diastolic function of the left ventricle at mitral valve prolapse

Malev E. G., Reeva S. V., Timofeev E. V.,Pshepiy A. R., Korshunova A. L., Pankova I. A., Zemtsovskiy E. V.

Keywords: myocardium deromations, mitral valve prolapse, left ventricular systolic dysfunction

DOI: 10.18087/rhfj.2012.1.1562

Relevance. Several studies showed reduced LV systolic function with Marfan disease and missing aortic regurgitation, which allowed us to assume possible myocardium dysfunctions, and with other hereditary connective tissue disorders. Objective. Assessment of LV function in asymptomatic young patients with mitral valve prolapse (MVP), without significant mitral regurgitation (МР) by spackle-tracking method. Materials and methods. 78 patients with MVP (mean age 19.7±1.6 years; 72 % male) were enrolled to the study. 80 healthy volunteers of comparable age were included to the control group. Axial deformation and deformation rate (DR) of myocardium were evaluated in three apical sections by spackle tracking (Vivid 7 Dim, EchoPAC’06, GE), frame frequency 50–55 per sec. Results. Two clusters of patients with MVP were allocated. The 1st cluster (17 patients, 28 % of all MVP group) showed significant decrease of global and regional axial systolic deformation and diastolic DR in comparison with the control group and the 2nd cluster (61 patients, 72 %). Global strain in the 2nd cluster did not differ significantly from the control group, but there were significant differences of local axial systolic deformations and diastolic DR: decrease in the septum and increase in the lateral, posterior and inferior walls. Conclusion. Use of modern hi-tech study methods allowed us to reveal several features of myocardium deformation characteristic of young asymptomatic MVP patients, which can be the first signs cardiomyopathy in hereditary connective tissue disorders, noogenesis of which requires further studies with use of magnetic resonance imaging and assessment of fibrosis markers.
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Malev E. G., Reeva S. V., Timofeev E. V. et al. Systolic and diastolic function of the left ventricle at mitral valve prolapse. Russian Heart Failure Journal. 2012;13(1):26-31

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