Liver function in patients with chronic heart failure in interrelation with clinical and hemodynamic parameters
Abdullaev T. A., Saburov M. Yu., Mardanov B. U., Akhmatov Ya. R.
Keywords: haemodynamics, clinical picture, hepatic function, CHF
Relevance. Hepatic lesion is a relatively common complication of CHF, which sets on as congestive hepatopathy conditioned by inferior vena cava hypertension. The development of this condition severely aggravates the course of main disease. Objective. Comparative study of liver lesions of various etiologies in CHF patients in interrelation with clinical and hemodynamic parameters. Materials and methods. 82 patients with CHF conditioned by ischemic and idiopathic dilated cardiomyopathies were enrolled to the study. All patients underwent examination of clinical state, CHF FC verification and assessment of exercise tolerance by means of 6‑minute walking test, as well as transthoracal echoCG and biochemical blood analysis. Results. In some third of patients with CHF of various etiologies and without primary liver lesion, clinical and laboratory signs of hepatic dysfunction were revealed, including the development of cirrhosis. Hyperbilirubinemia was noted to be the most common manifestation of hepatopathy. Hypoalbuminemia and hypolipidemia accompanied by more pronounced signs of the remodeling of both right and left heart were registered more often in CHF patients with signs of hepatic dysfunction. Conclusion. The obtained data do not answer many questions concerning the direction of the revealed interrelation (primary nature of the process), role of dysfunction of other organs (due to lack of perfusion) in the development of the described changes, which makes it necessary to continue studies in this area.
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Abdullaev T. A., Saburov M. Yu., Mardanov B. U. et al. Liver function in patients with chronic heart failure in interrelation with clinical and hemodynamic parameters. Russian Heart Failure Journal. 2012;13(1):9-12